TL;DR: A 2026 mouse study in Cell Reports found that FGF21, a liver hormone released during protein restriction, acts on hindbrain NTS-KLB neurons to change protein seeking, food choice, and energy use. Key Findings NTS-KLB neurons were required and could recreate the response: Removing these hindbrain neurons blocked food-intake, food-choice, and energy-expenditure changes during protein …
TL;DR: A 2026 paper in ACS Omega used real-time fluorescence anisotropy to show that Ni-bme-dach selectively reversed copper-driven amyloid-beta aggregation. Key Findings Real-time copper-aggregation kinetics: TAMRA-labeled Aβ anisotropy rose from ~0.12 to 0.20 as copper drove aggregation — a clean readout that nanoscale assemblies were forming. Ni-bme-dach reversed the copper readout selectively: The selective chelator …
TL;DR: A 2014 paper in Nature linked Huntington disease’s striatal vulnerability to CSE loss and cysteine depletion, with cysteine supplementation reversing abnormalities in models. Key Findings Cysteine supplementation reversed abnormalities: The strongest causal piece — restoring the downstream metabolite improved disease-relevant outcomes in both cell culture and intact mouse models. CSE was depleted in Huntington …
TL;DR: A 2026 study in Cell Stem Cell found that dementia-resilient Alzheimer’s brains retained rare immature hippocampal neurons with stronger survival-related gene programs and less inflammation. Key Findings Cell behavior, not cell count, marked resilience: Immature neurons existed across donor groups. The difference was the gene programs they ran — coping, survival, lower inflammation, reduced …
TL;DR: A 2026 paper in Gastroenterology found that early-life stress produced lasting visceral pain and motility changes through enteric and sympathetic nerve pathways in mice. Key Findings Chemical sympathectomy restored motility: The strongest causal piece — reducing sympathetic drive normalized stress-induced gut dysfunction in adult mice. The phenotype was actively maintained, not a fixed scar. …
TL;DR: A 2025 mouse study in Nature Communications found early locus coeruleus axon loss in the olfactory bulb before heavy plaque buildup, offering a mechanism for Alzheimer’s-related smell loss. Key Findings TSPO knockout rescued smell: Cutting microglial phagocytosis preserved locus coeruleus axons and restored buried-food performance toward wild-type levels — the strongest causal piece. 60% …
TL;DR: A 2026 protocol paper in Neurological Research and Practice described the MSpine trial, which is testing whether whole-spinal-cord MRI detects silent MS lesions missed by brain MRI. Key Findings 31.2% of spinal lesions may be asymptomatic: Prior retrospective data suggest nearly a third of new cord lesions produce no symptoms, meaning symptom-triggered imaging misses …
TL;DR: A 2026 meta-analysis in Psychological Medicine reported that AVATAR therapy matched CBT immediately after treatment and outperformed it at 3 months for distressing voices. Key Findings No clear edge at treatment end: AVATAR did not significantly beat CBT on voice severity right after therapy ended (SMD = −0.23, 95% CI −0.55 to 0.10) — …
TL;DR: A 2026 study in Nature Medicine found that people carrying Parkinson’s-linked GBA1 variants already showed gut microbiome differences before motor symptoms appeared. Key Findings Pre-symptomatic gut looked intermediate: About 25% of the Parkinson’s-linked microbiome component in non-manifesting GBA1 carriers sat between healthy controls and diagnosed patients — not fully normal, not fully Parkinsonian. 176 …
TL;DR: A 2026 study in Alzheimer’s & Dementia linked SuperAging to preserved cortex, larger entorhinal neurons, less inflammatory microglia, and more von Economo neurons. Key Findings Age-80 memory matched 50-to-60-year-olds: SuperAgers are defined as adults ≥80 whose delayed word recall equals or exceeds performance typical of people 20–30 years younger. “Normal” aging hides a lot …
