Medical

Guanfacine Reverses Cognitive Impairment in Long COVID (2024 Case Report)

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Guanfacine extended release (GXR) may effectively improve cognitive impairments and brain activity in long-COVID patients. Highlights: Patient Presentation: A 32-year-old woman experienced cognitive impairments such as difficulty in word recall, reading, and writing, and delayed task completion following COVID-19 infection. Baseline Assessment: Initial tests showed poor performance in attention, working memory, and executive function, with …

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ACOT7 Biomarker May Help in Early Diagnosis of Alzheimers Disease (2024 Study)

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ACOT7 shows promise as a non-invasive serum biomarker for Alzheimer’s disease (AD) with high diagnostic accuracy. Highlights: Increased Expression: ACOT7 levels were significantly elevated in AD patients and animal models compared to controls. Correlation with Cognitive Decline: A strong negative correlation was observed between serum ACOT7 levels and MMSE scores (r = -0.85; p < …

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Targeting the Gut Microbiome to Treat Epilepsy & Seizures: Future Potential (2024 Research)

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Gut microbiota may influence epilepsy, but the exact mechanisms and involved microbiota are unclear, with potential treatments including ketogenic diets, probiotics, and fecal microbiota transplants being explored. Highlights: Approximately 33% of epilepsy patients are resistant to all antiseizure medications, with the role of gut microbiota in epilepsy being increasingly evident. The gut-brain axis, involving neuroendocrine, …

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Nanoparticle Enhanced Radiotherapy (NERT) for Brain Tumor Treatment (2024 Research)

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Nanoparticle-enhanced radiotherapy (NERT) is a promising approach to improving brain tumor treatment by enhancing radiotherapy efficacy through targeted delivery and radiosensitization while overcoming challenges posed by the blood-brain barrier. Highlights: Mechanisms of Action: NERT utilizes nanoparticles (NPs) as radiosensitizers, enhancing radiation-induced damage through physical dose enhancement and biological/chemical sensitization. Types of Nanoparticles: Various NP types, …

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Mitochondrial Dysfunction Linked to Psychiatric Disorders Like Autism & ADHD (2024 Study)

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A study found a strong link between mitochondrial disorders and conditions like autism, ADHD, and various psychiatric issues. Highlights: Common Link: Mitochondrial disorders are frequently found in people with autism, ADHD, and intellectual disabilities. ASD Emphasis: Most research focused on autism, suggesting it might be more strongly linked to mitochondrial issues or simply better funded. …

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Repurposing Antipsychotics & Antidepressants to Treat Glioblastoma (2024 Study)

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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of Action: The studied antipsychotics and antidepressants induce GBM cell death by disrupting lysosomal function, leading to lysosomal membrane rupture. PTEN Sensitivity: GBMs with intact PTEN …

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Psychosocial Factors Linked to Dizziness & Chronic Dizziness (2024 Research)

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Psychosocial factors such as stress and depression, along with physical health issues like tympanic abnormalities and diabetes, significantly contribute to dizziness and chronic dizziness in adults. Highlights: Prevalence & Chronicity: Dizziness affected 24.6% of adults, with 17.1% of these experiencing chronic dizziness (≥3 months). Psychosocial Factors: Female sex, high levels of stress, and depression were …

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Serotonin (5-HT) vs. Tumors & Cancers: Potential Immunomodulation Treatment (2024 Research)

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Cancer patients frequently experience depressive symptoms, and the role of serotonin in tumor regulation varies across different types. Highlights: Prevalence of Depression in Cancer Patients: A significant portion of cancer patients experience depressive symptoms, which are often linked to neuroendocrine hormone imbalances and decreased serotonin levels. Neuroimmunology’s Role: Neuroimmunology is an emerging field that has …

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PCSK9 Inhibitors May Increase Parkinson’s Disease & Reduce ALS Risk (2024 Study)

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PCSK9 inhibitors significantly reduce the risk of amyotrophic lateral sclerosis (ALS) but increase the risk of Parkinson’s disease (PD). Highlights: ALS Risk Reduction: PCSK9 inhibitors marginally reduced the risk of ALS with an odds ratio of 0.89 (p = 0.048). PD Risk Increase: PCSK9 inhibitors increased the risk of Parkinson’s disease, with an odds ratio …

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Hypertension Linked to Impaired Cognition & Gait in Older Adults (2024 Study)

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Hypertension in older adults leads to poorer cognitive and walking performance due to the need for more brain resources to manage dual tasks. Highlights: Older adults with hypertension show higher brain activation in motor and sensory areas when performing dual cognitive-walking tasks compared to healthy peers. Hypertensive individuals have worse cognitive performance on single cognitive …

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