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TL;DR: In female mice without ovaries, a model of menopause, the osteoporosis drug raloxifene and the hormone progesterone each protected brain dopamine from a toxin that mimics Parkinson’s. Giving both together worked no better than either alone. Key Findings…
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TL;DR: In a 40-person stroke rehab trial, people who did video-game balance training with a tight cuff on the weak thigh improved balance, walking and leg strength more over 4 weeks than people doing the same training without the cuff. The trial was small, sho…
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TL;DR: Mouse studies of spinal muscular atrophy have reported anywhere from no loss to 60% loss of motor neurons, and a German-American team found that which slice of spinal cord gets counted explains much of that spread. Counting the right segments with a rel…
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TL;DR: A Swedish study of 42 people with depression found no link between the brain’s main calming chemical, GABA, and slowed movement, early waking or poor appetite. The researchers measured GABA with two kinds of scans, but most patients had fairly mild vers…
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TL;DR: In 86 people from one hospital in China, those with Parkinson’s and mild thinking problems showed changes in how water moves through parts of the hippocampus, a memory center. The hippocampus was not measurably smaller, suggesting a diffusion scan may p…
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TL;DR: Thin nerve fibers in the mouse brain are not smooth tubes but look like strings of tiny pearls, a shape set by the physics of their outer membrane. Changing that shape with drugs or heavy activity sped up or slowed down nerve signals by roughly 14% to 2…
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TL;DR: In mice with a painful, inflamed paw, two separate sets of neurons in a pain-and-emotion brain area seemed to drive different side effects. One set, wired to the amygdala, controlled anxiety-like behavior, while the other, wired to a reward hub, control…
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TL;DR: Two research teams used different methods to map the brain’s wiring in the same 1,065 young adults, then checked for differences between men and women. They almost always agreed on the fiber-quality measures, clashing just once in 343 comparisons, but d…
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TL;DR: In mice, the bone marrow inside the skull holds small immune hubs that pick up proteins leaking out of the brain and react to them, including proteins from brain tumors. Boosting those hubs with a gel placed under the scalp helped mice with brain tumors…
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TL;DR: Stroke patients whose brain arteries showed tiny traveling clots on an ultrasound scan had nearly 3 times the odds of poor recovery than those without, across 13 studies. The signals may mark a more unstable stroke rather than cause the worse outcome. K…
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