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TL;DR: A 2026 mouse study in Nature Communications reported that 10 daily bouts of optogenetic dentate-gyrus stimulation produced weeks-long changes in chromatin, nuclear structure, behavior, and spatial coding, while Cyclin B deletion weakened several effects…
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TL;DR: A 2026 randomized study in Psychological Medicine reported that 7–10 days of prucalopride improved word-learning recall and working-memory response speed versus placebo in adults with remitted recurrent depression, but the 49-person analysis did not tes…
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TL;DR: A 2026 study in Science Advances reported that disrupting the membrane-associated periodic skeleton (MPS), an actin-spectrin lattice beneath neuron membranes, reduced the fitted amyloid precursor protein (APP) uptake time constant in cultured mouse hipp…
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TL;DR: A 2026 mouse study in Gene Therapy used an adeno-associated virus 9 (AAV9) vector to deliver human FMR1 and reduced sound-triggered seizures, excessive digging, and gamma-frequency electroencephalography (EEG) power in selected dose and route groups. Th…
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TL;DR: A 2026 Phase 2 trial in The British Journal of Psychiatry found that 10 mg emestedastat did not improve attention and working memory after six weeks in adults with major depressive disorder and objectively measured cognitive impairment. A nominal depres…
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TL;DR: A 2026 mouse study in Translational Psychiatry reported that six days of adolescent THC exposure reduced Reelin-positive cell density in the female prefrontal cortex and cortical thickness across sexes. Prenatal immune activation did not consistently ma…
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TL;DR: A 2026 study in PLOS One found that emergency call takers and dispatchers who used more negatively valenced words when describing a stressful work event reported higher depression and anxiety symptoms, while arousal-related language did not predict dist…
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TL;DR: A 2026 study in Journal of Medical Internet Research found that psychology trainees were generally open to artificial intelligence-based precision mental health technologies (AI-PMHTs), but fear, perceived risk, resistance to change, and reliability con…
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TL;DR: A 2026 preprint in medRxiv tested an interpretable machine-learning model for focal cortical dysplasia (FCD), a lesion linked to drug-resistant epilepsy, and found that hemispheric-asymmetry MRI features classified 39 of 50 subjects correctly in leave-o…
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TL;DR: A 2026 review in Journal of Neuroinflammation proposed that Alzheimer microglial dysfunction can be understood as checkpoint collapse, where failed regulatory controls feed three interacting lipid, iron/ferroptosis, and inflammation/complement axes. Key…
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