Medical

Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

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Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

TL;DR: A 2026 study in Translational Psychiatry combined positron emission tomography (PET) and functional MRI (fMRI) in alcohol use disorder and linked cerebellar hypermetabolism to disrupted fronto-cerebellar connectivity and poorer inhibition performance. Key Findings AUD-control sample: Researchers compared 27 people with severe alcohol use disorder (AUD) and 25 healthy controls. Multimodal imaging used: The study …

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Phobic Anxiety Predicted Depression Treatment Response in Self-Report Study

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Phobic Anxiety Predicted Depression Treatment Response in Self-Report Study

TL;DR: A 2026 longitudinal study in Journal of Korean Medical Science found that self-reported phobic anxiety on the Symptom Checklist-90-Revised helped predict 2-month depression treatment response even when baseline clinician-rated depression and anxiety scores were similar. Key Findings Mood-disorder cohort was followed: The cohort included 157 people with major depressive disorder or bipolar disorder who …

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Fisetin Plus Training Improved Maresin-1 and HOMA-IR in Obesity Trial

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Fisetin Plus Training Improved Maresin-1 and HOMA-IR in Obesity Trial

TL;DR: A 2026 randomized trial in Journal of the International Society of Sports Nutrition found that 12 weeks of combined interval resistance and aerobic training increased Maresin-1, an inflammation-resolving lipid mediator, in men with obesity, with the largest insulin-resistance improvement when training was paired with 200 mg/day fisetin. Key Findings 44 men completed the trial: …

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Post COVID-19 Condition Linked to Fatigue, Sleep, Mood, and Subjective Cognition

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Post COVID-19 Condition Linked to Fatigue, Sleep, Mood, and Subjective Cognition

TL;DR: A 2026 cross-sectional study in PLOS One found that people with post COVID-19 condition reported worse quality of life, fatigue, sleep, psychological wellbeing, and subjective cognition than COVID-19 survivors without the condition, while many objective lung, metabolic, and cognitive tests did not differ. Key Findings 139-person Dutch cohort: The study included 87 people with …

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Alzheimer Plasma Proteomics Favored Continuous Molecular Axes

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Alzheimer Plasma Proteomics Favored Continuous Molecular Axes

TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The discovery analysis used one record per participant from the Global Neurodegeneration Proteomics Consortium. 81.5% module-space variance: Four continuous …

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Alzheimer Biomarker-Clock Analysis Can Create Countdown Paradox

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Alzheimer Biomarker-Clock Analysis Can Create Countdown Paradox

TL;DR: A 2026 preprint in medRxiv warned that a standard Alzheimer’s disease biomarker-clock analysis can create a countdown paradox, where later biomarker-clock ages appear linked to faster mild cognitive impairment onset because of the way remaining time is calculated. Key Findings 100% false positives in simple null simulations: The standard countdown analysis rejected the null …

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DLPFC Pain Maps Converged in Brodmann Areas 8, 9, and 46

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DLPFC Pain Maps Converged in Brodmann Areas 8, 9, and 46

TL;DR: A 2026 review and activation-likelihood estimation study in European Journal of Pain found that the dorsolateral prefrontal cortex (dlPFC), a frontal control region, was repeatedly engaged in acute pain, chronic pain, and placebo analgesia, mainly across Brodmann areas 8, 9, and 46. Key Findings 138 studies included: The review screened 4810 deduplicated records and …

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GRANPA Let Diphenhydramine Inhibit Brain Circuits in Mouse Models

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GRANPA Let Diphenhydramine Inhibit Brain Circuits in Mouse Models

TL;DR: A 2026 study in Signal Transduction and Targeted Therapy engineered a modified inhibitory DREADD receptor called GRANPA so the over-the-counter antihistamine diphenhydramine could switch off targeted brain circuits and reduce seizure activity in mouse models. Key Findings Two added receptor mutations: The lead GRANPA receptor combined hM4Di with S85V and Y416F mutations to improve …

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Ketamine and Synthetic Cathinones Appeared in Italian ED Drug Toxicity Cases

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Ketamine and Synthetic Cathinones Appeared in Italian ED Drug Toxicity Cases

TL;DR: A 2026 observational study in International Journal of Legal Medicine found that cocaine dominated analytically confirmed recreational drug toxicity cases in one Bologna emergency department, while ketamine was common and all new-psychoactive-substance-positive patients had psychomotor agitation. Key Findings 110 ED patients: The observational study enrolled 110 patients with suspected acute recreational drug toxicity between …

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Immersive VR Reduced Anxiety and Pain in Gastrointestinal Cancer Trials

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Immersive VR Reduced Anxiety and Pain in Gastrointestinal Cancer Trials

TL;DR: A 2026 systematic review and meta-analysis in Journal of Medical Internet Research found that immersive virtual reality reduced anxiety and pain in randomized trials of gastrointestinal cancer care, but wide prediction intervals and low evidence certainty mean the effect may vary across clinical settings. Key Findings 14 RCTs: The review included 14 randomized controlled …

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