TL;DR: A 2026 preprint longitudinal cohort analysis in medRxiv found that later-born cohorts showed higher memory levels entering old age and slower rates of memory decline, while the projected 20-year cohort advantage at age 80 was large enough in the model to account for a reported 13% per-decade decline in dementia incidence. Key Findings Birth-cohort …
TL;DR: A 2026 Human Brain Mapping study combined PET receptor imaging with speech functional MRI, or fMRI, in healthy adults and found that GABA signaling and striatal dopamine release interacted with brain activity during human speech control. Key Findings PET-fMRI sample: The study included 17 right-handed volunteers, with mean age about 53 years. Receptor tracers …
TL;DR: A 2026 randomized clinical trial in JAMA Network Open found that one supervised 30 mg/70 kg psilocybin dose plus cognitive behavioral therapy produced 40.5% six-month smoking abstinence versus 10.0% with a nicotine patch plus the same therapy. Key Findings 40.5% vs. 10% prolonged abstinence at 6 months: 17 of 42 psilocybin participants stayed biochemically …
TL;DR: A 2026 randomized trial analysis in European Journal of Psychotraumatology found that COPE-A, an integrated exposure-based therapy for youth with posttraumatic stress disorder (PTSD) and substance use disorder (SUD), reduced PTSD symptoms more than supportive counseling, but substance-use reductions were not significantly stronger than counseling. Key Findings 49 treated participants were analyzed: Youth aged …
TL;DR: A 2026 medRxiv preprint applied the AT(N) framework, an Alzheimer’s disease biomarker system for amyloid, tau, and neurodegeneration, to 84 older adults with focal epilepsy and found that only 32.1% had normal blood biomarkers, while early-onset epilepsy carried higher odds of biomarker abnormality. Key Findings Epilepsy cohort: Researchers analyzed focal epilepsy participants from the …
TL;DR: A 2026 study in npj Mental Health Research found that a 308-person multimodal MRI study found treatment-resistant depression carried a distinct structure-function decoupling pattern, and machine-learning models separated TRD from non-resistant depression with AUCs up to 0.95. Key Findings 72 TRD patients analyzed: The final sample included 72 patients with treatment-resistant depression, 152 with …
TL;DR: A 2026 preprint in medRxiv trained machine-learning models on Danish electronic health records and found that an XGBoost model predicted clozapine initiation within 365 days with an AUROC of 0.81 in patients with schizophrenia or schizoaffective disorder. Key Findings 229,761 prediction times: The main model used routine psychiatric hospital contacts from 5,806 patients after …
TL;DR: A 2026 study in O&G Open found that cannabis exposure 2–7 years after a first pregnancy was not associated with incident hypertension after adjustment in the nuMoM2b Heart Health Study. Key Findings No adjusted hypertension association: Cannabis exposure was not associated with incident hypertension after adjustment (AOR 1.05; 95% CI, 0.63-1.76). 4,079-person analysis: Researchers …
TL;DR: A 2026 study in The British Journal of Psychiatry found that people with anxiety disorders showed hyper-scanning during neutral image viewing and hyper-pursuit during moving-dot tracking, suggesting that eye-tracking could capture measurable patterns of anxiety-related vigilance. Key Findings 307-person sample: Researchers compared 91 patients with anxiety disorders, 118 with depressive disorders, and 98 healthy …
TL;DR: A 2026 in vitro study in Molecular and Clinical Oncology found that amitriptyline reduced C6 glioma cell viability and PD-L1 checkpoint expression, but the same drug weakened the cell-killing effect of radiation when combined with temozolomide. Key Findings Amitriptyline alone reduced glioma cell growth: In non-radiated C6 glioma cultures, 10 micromolar amitriptyline lowered viability …
