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Estradiol enhances memory and other aspects of cognition in animals and humans, but translating the research into effective hormone replacement therapies (HRTs) has faced challenges. Recent developments indicate multiple mechanisms, along with some key facts:…
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Researchers explore various drug compounds and their potential to enhance human cognition, including attention, learning, and higher-order thinking. While some progress has been made, many questions remain. Key Facts: Several drug compounds show potential to m…
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Major depressive disorder (MDD) is a global health crisis affecting over 300 million people. While available antidepressants help some patients, treatment is far from satisfactory for many. Exciting research into rapid-acting agents like ketamine and psilocybi…
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Antidepressants could potentially be repurposed as anticancer agents based on emerging evidence showing they can modulate autophagy—a process cancer cells rely on for growth and survival. Key Facts: Many antidepressants like SSRIs and TCAs have demonstrated an…
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New research finds that regular running is just as effective as antidepressants for treating depression and anxiety, and leads to better physical health outcomes. Key Facts: In a study of 141 patients, running therapy and antidepressant medication had comparab…
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Depression affects over 300 million people globally. Current antidepressants have limited efficacy and slow onset of action. New research shows promise for compounds targeting metabotropic glutamate receptors 2 and 3 (mGluR2/3) as fast-acting antidepressants w…
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Neurofeedback is a promising technique that allows people to voluntarily control their own brain activity with the goal of improving cognitive functions or relieving symptoms. Key Facts: Neurofeedback provides real-time feedback on brain activity, allowing a p…
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New research reveals that increased inflammation, indicated by higher levels of a protein called VCAM-1, is associated with decreased gray matter and altered brain connectivity in patients with major depressive disorder (MDD). These brain changes also correlat…
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A new study examined whether metabolic biomarkers assessed through a high-throughput method are associated with future depressive symptoms. The results suggest the metabolites may not play a direct role in depression development. Key Facts: Researchers investi…
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Researchers have made strides towards enabling personalized dosing for the commonly prescribed antidepressant escitalopram. Using robust clinical trial data, they developed an innovative population pharmacokinetics model that elucidates the impact of patient g…
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