TL;DR: A 2026 preprint in medRxiv reported that an interpretable CatBoost machine-learning model predicted stroke-associated pneumonia after acute ischemic stroke bridging therapy with a test-set AUC of 0.932, with 7-day stroke severity and early inflammatory markers among the strongest contributors. Key Findings 135 stroke patients: The retrospective analysis included 135 acute ischemic stroke patients who …
TL;DR: A 2026 study in BJGP Open found no clear cohort-level increase in major bleeding outcomes when selective serotonin reuptake inhibitors (SSRIs) were used with direct oral anticoagulants (DOACs), but the self-controlled analysis still pointed to extra caution when an SSRI is newly started during DOAC treatment. Key Findings No cohort increase: DOAC plus SSRI …
TL;DR: A 2026 study in Glia used human single-nucleus RNA sequencing datasets and mouse validation to identify a shared neurodegeneration-linked microglial transcription program, highlighting SPP1 as a disease-associated microglia marker. Key Findings Five disease contexts: The analysis integrated human microglia datasets from Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and aging. Single-nucleus RNA-seq: …
TL;DR: A 2026 systematic review in Cognitive, Affective, & Behavioral Neuroscience found that stroke and traumatic brain injury populations showed consistent social cognition alterations across domains, while insula, cingulate cortex, middle frontal gyrus, and corpus callosum were repeatedly implicated. Key Findings Study type: a PRISMA-guided systematic review of social cognition domains after stroke and traumatic …
TL;DR: A 2026 uncontrolled pilot study in BJPsych Open found that SMART, a personalized text-message program for metabolic health in people with schizophrenia spectrum disorders, improved patient activation, diabetes self-management confidence, health literacy, and recovery scores over 12 weeks, while objective cardiometabolic markers did not significantly change. Key Findings SMART reached a schizophrenia-risk group: Researchers …
TL;DR: A 2026 mouse study in Nature mapped more than 76,000 single-neuron projections from the orofacial motor cortex (OMC) and found that Alston’s singing mouse, which produces audible song, has 2.8-fold higher OMC connectivity to an auditory cortical region and 3.3-fold higher OMC connectivity to the midbrain periaqueductal grey (PAG) than the laboratory mouse. Key …
TL;DR: A 2026 preprint in medRxiv reported that serum myelin oligodendrocyte glycoprotein (MOG) protein was higher in multiple sclerosis than controls and higher during clinical relapse than remission. Key Findings 20.5 pg/ml higher: Serum MOG protein was higher in MS than healthy donors by a mean difference of 20.5 pg/ml. 27.5 pg/ml higher: MS samples …
TL;DR: A 2026 study in PNAS from Oregon Health & Science University and Anhui University used optogenetics in mice to map a specific serotonin-producing brain circuit that runs straight to the auditory system, showed that activating this circuit produced tinnitus-like behavior, and traced a likely mechanism for why some patients on SSRI antidepressants report worsened …
TL;DR: A 2026 preprint in medRxiv reported that SenseCheQ, a home quantitative sensory testing device, produced reliable vibration and temperature-threshold measurements in 30 healthy adults and tracked early sensory changes in 3 breast cancer patients receiving neurotoxic chemotherapy. Key Findings 30-person home study: Healthy adults completed one familiarization session and three self-administered home sessions using …
TL;DR: A 2026 scoping review in Sleep Science linked seasonal timing, daylight exposure, daylight saving time (DST), sleep-wake rhythm disruption, and driver drowsiness to traffic-crash risk, but found that few studies directly integrate seasonality with chronobiology in one model. Key Findings 1,758 records screened: The scoping review used PRISMA-ScR methods and screened 1,758 records before …
