Exercise and Fluoxetine May Converge on Alzheimer’s Disease Mechanisms

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Exercise and Fluoxetine May Converge on Alzheimer's Disease Mechanisms

TL;DR: A 2026 review in International Journal of Molecular Medicine mapped how exercise and fluoxetine overlap in Alzheimer’s disease mechanisms such as mitochondrial quality control, oxidative stress, inflammation, and neuroplasticity, but clinical combination benefits remain unproven. Key Findings Review article, not trial: Wu and Li synthesized mechanistic evidence on exercise and fluoxetine in Alzheimer’s disease …

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Choroid Plexus Enlargement Linked to Progressive MS Myo-Inositol Signal

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Choroid Plexus Enlargement Linked to Progressive MS Myo-Inositol Signal

TL;DR: A 2026 preprint posted on medRxiv reported that larger choroid plexus volume on brain MRI was associated with greater disability in multiple sclerosis and with higher white-matter myo-inositol in progressive MS, but the work has not yet been peer reviewed. Key Findings 88-person imaging sample: Researchers studied 45 people with multiple sclerosis and 43 …

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Celiac Disease Presented With Chronic Insomnia in Single Case Report

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Celiac Disease Presented With Chronic Insomnia in Single Case Report

TL;DR: A 2026 case study in International Medical Case Reports Journal described a 42-year-old man whose chronic insomnia improved after celiac disease was diagnosed and treated with a gluten-free diet, but the report cannot prove gluten exposure caused the sleep problem. Key Findings 5 months of insomnia: The patient reported persistent difficulty initiating and maintaining …

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Bipolar Medication Nonadherence Linked to Substance Use and Low Insight

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Bipolar Medication Nonadherence Linked to Substance Use and Low Insight

TL;DR: A 2026 systematic review and meta-analysis in Bipolar Disorders found that poor medication adherence in bipolar disorder was linked to substance use, psychotic features, lower insight, poorer functioning, and several markers of more severe illness, but most evidence was graded low or very low quality. Key Findings 19 studies included: Researchers pooled observational studies …

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High-Conflict Divorce Linked to Higher Healthcare Use Over 10 Years

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High-Conflict Divorce Linked to Higher Healthcare Use Over 10 Years

TL;DR: A 2026 Danish register study in British Journal of Health Psychology found that higher divorce conflict was linked to more prescriptions, more primary care visits, and higher hospitalisation odds across the years around legal divorce. Key Findings 1,784 Danish divorcees: Researchers linked divorce-conflict survey data to national registers covering medicine prescriptions, primary care visits, …

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Celecoxib Add-On to Antidepressants Reduced Depression Scores: Evidence Very Uncertain

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Celecoxib Add-On to Antidepressants Reduced Depression Scores: Evidence Very Uncertain

TL;DR: A 2026 systematic review and meta-analysis in Brain, Behavior, & Immunity – Health found that adding celecoxib to antidepressants was linked to lower depressive symptom scores in 7 small trials, but the efficacy evidence was rated very low certainty. Key Findings 7 randomized trials: The meta-analysis included 365 adults with major depressive disorder, with …

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Choroid Plexus Volume Increased in Alzheimer’s MRI Meta-Analysis

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Choroid Plexus Volume Increased in Alzheimer's MRI Meta-Analysis

TL;DR: A 2026 systematic review and meta-analysis in Journal of Alzheimer’s Disease found that choroid plexus volume, an MRI-visible structure involved in cerebrospinal-fluid regulation and immune signaling, was larger in Alzheimer’s disease than in healthy controls. Key Findings Sixteen studies: The review included 16 MRI-based studies covering 2,004 Alzheimer’s disease patients and 883 healthy controls. …

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Neuropsychiatric Genetic Risk Mapped Fluid and Crystallized Cognition

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Neuropsychiatric Genetic Risk Mapped Fluid and Crystallized Cognition

TL;DR: A 2026 study in Nature Communications found that neuropsychiatric disorder risk did not map onto cognition as one general trait. Schizophrenia, bipolar disorder, ADHD, autism, and Alzheimer’s disease showed different genetic links with reaction time, fluid reasoning, crystallized knowledge, and noncognitive educational skills. Key Findings 439,000-person GWAS scale: The crystallized-knowledge genome-wide association study had …

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Very Low Nicotine Cigarettes Increased Alternative Nicotine Use

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Very Low Nicotine Cigarettes Increased Alternative Nicotine Use

TL;DR: A 2026 secondary analysis in Addiction found that adults switched to very-low-nicotine cigarettes often used alternative nicotine products and maintained much higher nicotine intake than cigarette-only users. Key Findings 438 smokers: The parent randomized clinical trial enrolled adults who smoked 5 to 40 cigarettes per day. 0.4 mg/g cigarettes: The very-low-nicotine-content group received Spectrum …

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Systematic Review Identified Limited Medication Signals for Online Addictions

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Systematic Review Identified Limited Medication Signals for Online Addictions

TL;DR: A 2026 systematic review in Future Science OA found early medication evidence for online behavioral addictions, but the 20 included studies were mostly small, male-heavy, and short-term. Key Findings Medication evidence stayed early: The review found small, mixed pharmacotherapy signals across 20 online behavioral addiction studies. Clinical groups stayed small: The 1,016 total participants …

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