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TL;DR: Old female mice given plasmalogens, a fat found in brain cell membranes, 5 days a week for 2 months did better on a memory maze than old mice given water. Their brains also showed more synapses and less inflammation, but this is a mouse study, not a hum…
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TL;DR: A 2026 review in Journal of Neuroinflammation proposed that Alzheimer microglial dysfunction can be understood as checkpoint collapse, where failed regulatory controls feed three interacting lipid, iron/ferroptosis, and inflammation/complement axes. Key…
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TL;DR: A 2026 review in the Journal of Neuroinflammation argued that several parasitic infections may affect behavior and cognition through converging microbiota, immune, barrier, and glial pathways. Key Findings Protozoa and helminths reviewed: The review cov…
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TL;DR: A 2026 Nature Neuroscience study used cross-species functional MRI (fMRI) connectivity to identify hypoconnectivity and hyperconnectivity autism subtypes linked to different synaptic and immune-related biological pathways. Key Findings 20 mouse models:…
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TL;DR: A 2026 review in Purinergic Signalling argues that ATP-gated P2X receptors, especially P2X7 and P2X4, may connect stress-related neuroinflammation with depression and bipolar-disorder biology. Key Findings P2X7 focus: The review describes P2X7 receptor…
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TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatme…
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TL;DR: A 2026 systematic review in Molecular Psychiatry found that microglia-related findings across major depression, bipolar disorder, and schizophrenia were better explained by biological subgroups than by one uniform diagnosis-by-diagnosis inflammation pat…
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TL;DR: A 2026 medRxiv preprint reanalyzed long-term survivors from the AB10015 ALS trial and reported that masitinib-treated patients had higher 5-year survival than historical benchmarks, but the analysis was post hoc, sponsor-supported, and lacked long-term…
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TL;DR: A 2026 Reviews in the Neurosciences review argues that glycolysis, the cell pathway that turns glucose into usable energy and lactate, is a disease-shaping process across Alzheimer’s disease, Parkinson’s disease, ALS, Huntington’s disease, Wilson diseas…
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TL;DR: A 2026 rat and cell study in Journal of Materials Science: Materials in Medicine reported that an engineered VIN nanosystem shifted microglia toward an anti-inflammatory state and reduced ischemic-stroke infarct measures in MCAO rats. Key Findings CXCR4…
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