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TL;DR: A 2026 review in the Journal of Neuroinflammation argued that several parasitic infections may affect behavior and cognition through converging microbiota, immune, barrier, and glial pathways. Key Findings Protozoa and helminths reviewed: The review cov…
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TL;DR: A 2026 review in Drug Design, Development and Therapy argued that glucagon-like peptide-1 (GLP-1) receptor agonists, drugs that mimic a metabolic hormone involved in glucose control, have credible brain-protection mechanisms, but clinical evidence for n…
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TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health reported that Theiler’s murine encephalomyelitis virus (TMEV), a mouse neurotropic virus, infected substantia nigra dopamine neurons and produced Parkinson’s-like motor deficits in mice. Key Findings…
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TL;DR: A 2026 review in Purinergic Signalling argues that ATP-gated P2X receptors, especially P2X7 and P2X4, may connect stress-related neuroinflammation with depression and bipolar-disorder biology. Key Findings P2X7 focus: The review describes P2X7 receptor…
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TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatme…
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TL;DR: A 2025 mouse study in eNeuro reported that inhaled cannabidiol reduced IDO and cGAS pathway activity and lowered pro-inflammatory cytokines in male 5XFAD Alzheimer’s model mice. Key Findings 5XFAD model: The study used male 5XFAD transgenic mice, a comm…
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TL;DR: A 2026 study in Cureus found that a 55-year-old woman developed anxiety, somatic hypervigilance, and eventual delusional infestation after illicit cosmetic biopolymer injections, raising the possibility that chronic inflammatory exposure can help tip vu…
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TL;DR: A 2026 review in Journal of Pain Research argued that G protein-coupled receptor 30 (GPR30/GPER), a membrane estrogen receptor, could help connect estrogen fluctuations with migraine biology. Key Findings Female-predominant migraine: The review notes a…
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TL;DR: A 2025 study in Journal of the American Chemical Society found that a depression-linked gut bacterium now has a concrete inflammatory mechanism: Morganella morganii can make unusual phospholipids that activate TLR2/TLR1 and drive IL-6. Key Findings Morg…
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TL;DR: A 2026 review in Nature Reviews Neurology argued that neural extracellular matrix (ECM), the protein-and-glycan scaffold around central nervous system cells, is an active regulator of brain plasticity and neurological disease. Key Findings Multiple ECM…
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