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TL;DR: A 2026 randomized trial in JMIR mHealth and uHealth found that a 7-session CBT-based online self-help group reduced depression symptoms, with the average Beck Depression Inventory-II score moving from the moderate range to the mild range after the progr…
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TL;DR: A 2026 study protocol in PLOS One describes a planned longitudinal study that will track academic stress, depressive symptoms, diet, sleep-related wearable measures, salivary cortisol, and other health indicators across a university semester, but it doe…
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TL;DR: A 2026 cross-sectional study in PLOS One found that people with post COVID-19 condition reported worse quality of life, fatigue, sleep, psychological wellbeing, and subjective cognition than COVID-19 survivors without the condition, while many objective…
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TL;DR: A 2026 preprint in medRxiv analyzed plasma proteomics in Alzheimer’s disease and mild cognitive impairment and found that four continuous molecular axes described the data better than hard subtype labels. Key Findings 5,895-person AD/MCI sample: The dis…
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TL;DR: A 2026 preprint in medRxiv warned that a standard Alzheimer’s disease biomarker-clock analysis can create a countdown paradox, where later biomarker-clock ages appear linked to faster mild cognitive impairment onset because of the way remaining time is…
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TL;DR: A 2026 review in Brain Medicine found mixed randomized-trial evidence for creatine monohydrate as an add-on depression treatment: 2 of 5 trials showed symptom benefits, while 3 did not find a clear advantage. Key Findings Five randomized trials were rev…
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TL;DR: A 2026 review and activation-likelihood estimation study in European Journal of Pain found that the dorsolateral prefrontal cortex (dlPFC), a frontal control region, was repeatedly engaged in acute pain, chronic pain, and placebo analgesia, mainly acros…
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TL;DR: A 2026 study in Signal Transduction and Targeted Therapy engineered a modified inhibitory DREADD receptor called GRANPA so the over-the-counter antihistamine diphenhydramine could switch off targeted brain circuits and reduce seizure activity in mouse m…
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TL;DR: A 2026 randomized follow-up study in Maternal & Child Nutrition found no overall hair-cortisol difference at ages 9-11 after early-life small-quantity lipid-based nutrient supplementation, but children whose mothers had 0-5 years of schooling had lower…
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TL;DR: A 2026 study in Psychological Medicine found that sleep quality partly explained how early adolescent depression, anxiety, and psychotic-like experience distress were linked to later school grades and social problems in the Adolescent Brain Cognitive De…
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