TL;DR: A 2026 study in Journal of Health Psychology found that body roundness index identified dementia patients with higher odds of depressive symptoms better than body mass index did. Key Findings Threefold higher odds in the top BRI quartile: Among dementia patients, those in the highest body-roundness quartile had more than 3× the odds of …
TL;DR: A 2026 Markov model in PLOS Medicine found that esketamine improved treatment-resistant depression outcomes but was not cost-effective against cheaper third-line options in Hong Kong. Key Findings Antidepressant combination therapy was lowest-cost: One antidepressant plus another antidepressant cost US$16,163 per patient and produced 2.903 QALYs, the most cost-effective strategy in the model. Esketamine ICER …
TL;DR: A 2026 crossover trial in Journal of Korean Medical Science found that hearing aids outperformed personal sound amplifiers for high-frequency hearing, speech-in-noise, and user satisfaction. Key Findings Only hearing aids improved 4,000–6,000 Hz hearing: Both device classes helped 250–3,000 Hz, but the high frequencies that carry consonants — “s,” “f,” “th” — only improved …
TL;DR: A 2026 bioRxiv preprint found that repeated focused ultrasound changed blood-brain-barrier and microglial biology in Alzheimer’s rats without clearly improving pathology on its own. Key Findings Day 7 after 4 weekly sessions: Aβ42 and pTau231 went the wrong way: Aggregated Aβ42 rose (p = 0.0059), pTau231 rose (p = 0.0009). Repeated barrier opening alone …
TL;DR: A 2026 study in Molecular Psychiatry found lower cerebrospinal-fluid ethanolamine during active major depression, increases after ECT, and replication across four sites. Key Findings Active depression: 12.32 vs 14.07 µM: Active MDD patients had lower CSF ethanolamine than healthy controls (p = 0.00047) in a 380-person cohort. Remitted depression did not show the same …
TL;DR: A 2026 study in Circulation Research found that lateral parafacial expiratory neurons drove neurogenic hypertension in animal models, and silencing them lowered blood pressure. Key Findings Inactivation normalized blood pressure: Silencing the lateral parafacial region restored blood pressure to normal levels in the reported hypertensive model — the strongest causal piece of the paper. …
TL;DR: A 2026 review in The Lancet Psychiatry found that randomized-trial evidence remains too weak to support routine cannabinoid treatment for common mental disorders. Key Findings 54 RCTs, 2,477 participants total: Sounds substantial — until split across many disorders, compounds, doses, and outcomes. Most comparisons end up underpowered. No support for the most common use …
TL;DR: A 2025 study in Journal of Personality found that reactivating autonomy-frustrating memories made COVID conspiracy claims more believable, angering, and shareable in two Quebec experiments. Key Findings Subliminal memory cues moved real beliefs: Memory keywords flashed for just 60 ms — too fast for conscious reading — increased bogus-conspiracy endorsement, anger, and willingness to …
TL;DR: A 2026 randomized trial in The British Journal of Psychiatry found that six ketamine infusions improved treatment-resistant depression, while curated music added no measurable benefit. Key Findings MADRS fell 11.8 points by week 4: Scores dropped from 31.5 to 19.7 (d = 1.2, p < 0.001) across both groups — gains that held at …
TL;DR: A 2026 study in World Journal of Biological Psychiatry found that EEG connectivity between DLPFC and sgACC differed in depression patients who later remitted after rTMS. Key Findings Remitters had lower pre-treatment DLPFC-to-sgACC alpha connectivity: Baseline alpha-band isolated effective coherence (iCoh) — a directional measure — from left DLPFC to subgenual anterior cingulate cortex …
