Poor Sleep Tracked Faster Biological Aging, but Causation Was Mixed

Poor Sleep Tracked Faster Biological Aging, but Causation Was Mixed

TL;DR: A 2026 preprint in medRxiv found that poor sleep tracked faster biological aging across more than 64,000 adults, but twin and genetic analyses left the causal claim mixed rather than settled. Key Findings 64,000+ adults: Researchers tested sleep and aging biomarkers across five independent datasets spanning young, middle, and late adulthood. Poorer sleep quality: …

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Esketamine Stellate Ganglion Block Reduced Postoperative Sleep Disturbance

Esketamine Stellate Ganglion Block Reduced Postoperative Sleep Disturbance

TL;DR: A 2026 randomized trial in BMC Anesthesiology found that adding an esketamine-adjuvanted stellate ganglion block to intraoperative esketamine plus dexmedetomidine reduced early postoperative sleep disturbance after gynecological laparoscopic surgery. Key Findings Sleep disturbance fell on day 1: Postoperative sleep disturbance affected 62.9% of patients in the stellate ganglion block group versus 83.2% in controls. …

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Autistic Children With Speech Delay Showed Reversed Auditory Bias

Autistic Children With Speech Delay Showed Reversed Auditory Bias

TL;DR: A 2026 study in Autism Research found that autistic children with early speech delay needed longer sound gaps to detect timing changes, but detected smaller pitch-frequency changes than typically developing peers. Key Findings 21 autistic children were compared with 23 typically developing children: The autism group had early language delay and early autistic manifestations, …

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Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

TL;DR: A 2026 medRxiv preprint found that stroke thrombectomy operators often had a preferred device technique, but that preference did not reliably match the technique with the highest first-pass reperfusion rate. Key Findings Stroke thrombectomy cohort: The single-center analysis included 1,405 acute ischemic stroke patients treated with mechanical thrombectomy from 2019 through 2024. 75% had …

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Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

TL;DR: Portable electroencephalography (EEG) recordings tracked perinatal anxiety most consistently in a preliminary medRxiv preprint, with delta power carrying the clearest longitudinal marker and alpha power appearing in visit-specific anxiety analyses. Key Findings First-trimester marker: Relative delta power before 16 gestational weeks was associated with third-trimester PHQ-9 depression and GAD-7 anxiety scores. Delta-anxiety link: Across …

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Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

TL;DR: A 2026 qualitative study in the Journal of Substance Use and Addiction Treatment found that syringe service programs helped people receive buprenorphine quickly, but participants said precipitated withdrawal and limited at-home initiation guidance made treatment harder to start and continue. Key Findings 12 exit interviews: Researchers interviewed people after a randomized trial of buprenorphine …

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Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

TL;DR: A 2026 pilot study in The British Journal of Psychiatry tested psilocybin-assisted therapy in 21 adult females with anorexia nervosa and found lower Eating Disorder Examination (EDE) symptom scores through 6 months, with large individual variation and no placebo-controlled comparison. Key Findings Single-arm pilot study: Researchers enrolled 21 adult females with anorexia nervosa and …

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Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

Cerebellar Hypermetabolism Impaired Fronto-Cerebellar Connectivity in Alcohol Use Disorder

TL;DR: A 2026 study in Translational Psychiatry combined positron emission tomography (PET) and functional MRI (fMRI) in alcohol use disorder and linked cerebellar hypermetabolism to disrupted fronto-cerebellar connectivity and poorer inhibition performance. Key Findings AUD-control sample: Researchers compared 27 people with severe alcohol use disorder (AUD) and 25 healthy controls. Multimodal imaging used: The study …

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Metformin and Semaglutide Metabolic Clinic Reduced Weight in Severe Mental Illness

Metformin and Semaglutide Metabolic Clinic Reduced Weight in Severe Mental Illness

TL;DR: A 2026 retrospective chart review in Acta Psychiatrica Scandinavica found that a psychiatrist-led metabolic clinic helped 132 of 378 patients with severe mental illness lose at least 5% of baseline body weight over 12 months. Key Findings Clinic outcomes were tracked: Researchers analyzed 378 people treated at the Centre for Addiction and Mental Health …

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Oxytocin Plus Mindfulness Group Therapy Reduced Schizophrenia Negative Symptoms

Oxytocin Plus Mindfulness Group Therapy Reduced Schizophrenia Negative Symptoms

TL;DR: A 2026 preprint on medRxiv found that adding 24 IU intranasal oxytocin before 4 mindfulness-based group therapy sessions was linked to larger clinician-rated negative-symptom improvements in a small schizophrenia spectrum disorder pilot trial. Key Findings Oxytocin arm showed the main signal: The OXYMIND pilot assigned 26 outpatients to oxytocin plus mindfulness-based group therapy and …

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