TL;DR: A 2026 cohort study in The British Journal of Psychiatry found that lithium prescribing around pregnancy was rare in UK primary care records, and most pre-pregnancy lithium users did not stay on treatment through all three trimesters. Key Findings 752,112 pregnancies analyzed: Researchers used UK Clinical Practice Research Datalink GOLD records from 1995 to …
TL;DR: A 2025 study in Psychological Science found that depressive symptoms accelerated about 4 years before death in a multinational twin consortium, suggesting that late-life mood worsening can partly reflect terminal decline rather than chronological age alone. Key Findings 2,411 older-adult records: Researchers analyzed longitudinal depressive-symptom data from the Interplay of Genes and Environments across …
TL;DR: A 2026 fly study in IBRO Neuroscience Reports found that long-term rotenone exposure produced stronger survival, climbing, oxidative-stress, and late immune-gene disruption in male Drosophila than in female flies. Key Findings 90 flies per sex were tracked: Survival assays used three sets of 30 male or female flies after rotenone feeding. Two disease windows …
TL;DR: A 2026 systematic review in Molecular Psychiatry found that microglia-related findings across major depression, bipolar disorder, and schizophrenia were better explained by biological subgroups than by one uniform diagnosis-by-diagnosis inflammation pattern. Key Findings Three evidence streams: The review integrated human translocator protein positron emission tomography (TSPO-PET) imaging, cerebrospinal fluid kynurenine-pathway metabolites, and postmortem microglial …
TL;DR: A 2026 study in Psychiatry and Clinical Neurosciences Reports described a treatment-resistant residual-phase schizophrenia case in which valproate helped agitation but caused hypoglycemia and pancytopenia, while lithium augmentation was followed by lower hostility and excitement scores. Key Findings 49-year-old patient: The case involved a Japanese woman with chronic treatment-resistant schizophrenia and persistent agitation, aggression, …
TL;DR: A 2026 review in Journal of Pain Research argued that G protein-coupled receptor 30 (GPR30/GPER), a membrane estrogen receptor, could help connect estrogen fluctuations with migraine biology. Key Findings Female-predominant migraine: The review notes a female-to-male migraine prevalence ratio of about 2:1 to 3:1. Menstrual migraine link: About 50% to 60% of female migraineurs …
TL;DR: A 2026 claims analysis in Exploratory Research in Clinical and Social Pharmacy found that FDA-declared first-generation antipsychotic shortages were followed by medication switching in 9.13% of included patients with psychotic spectrum disorders, with especially high switching after thiothixene, trifluoperazine, and molindone shortages. Key Findings The claims cohort was large: 95,968 patients had a psychotic …
TL;DR: A 2026 review in Psychonomic Bulletin & Review explained how the Diffusion Model for Conflict tasks (DMC) models attention and cognitive control in Simon, Eriksen flanker, and Stroop tasks. Key Findings 3 classic tasks: The review focused on Simon, Eriksen flanker, and Stroop conflict tasks. 2 evidence streams: DMC combines a linear controlled stream …
TL;DR: A 2026 study in Psychological Medicine found that transcranial direct current stimulation (tDCS), a weak electrical brain-stimulation method, affected empathy differently depending on whether researchers targeted the right temporoparietal junction or the left dorsolateral prefrontal cortex. Key Findings Two brain targets diverged: right temporoparietal junction (rTPJ) stimulation strengthened cognitive empathy, while left dorsolateral prefrontal …
TL;DR: A 2026 systematic review posted on medRxiv found that transcranial direct current stimulation (tDCS), a weak noninvasive brain-stimulation method, added to cognitive training produced a small short-term cognitive benefit across 27 trials, but the effect faded at follow-up and the evidence certainty was very low. Key Findings 27 controlled studies: The meta-analysis included 1,012 …
