TL;DR: A reviewed preprint in eLife found that adult vestibular hair-cell kinocilia carry both primary-cilia and motile-cilia features, including motile-cilia gene signatures and spontaneous motion in bullfrog and mouse balance organs. Key Findings 1,522 mouse hair cells: The single-cell RNA-seq dataset included cochlear inner and outer hair cells plus vestibular type I and type II …
TL;DR: A 2026 preprint in medRxiv reported that a urine beta-amyloid protein test kit separated mild cognitive impairment or Alzheimer’s disease from healthy controls in a multicenter Chinese sample, while a 51,187-person community screen showed age-related positive rates. Key Findings 898-person validation sample: The multicenter case-control arm included 266 healthy controls, 167 people with mild …
TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health reported that Theiler’s murine encephalomyelitis virus (TMEV), a mouse neurotropic virus, infected substantia nigra dopamine neurons and produced Parkinson’s-like motor deficits in mice. Key Findings 13 TMEV mice vs 14 controls: The main behavioral experiment compared unilateral TMEV injection into the substantia nigra with …
TL;DR: A 2026 preprint in medRxiv reported that one session of left central thalamus focused ultrasound increased behavioral responsiveness scores in 16 adults with chronic disorders of consciousness, with no severe adverse events reported. Key Findings 16 chronic DOC patients: Adults had chronic disorders of consciousness after severe brain injury, with an average time since …
TL;DR: A 2026 review in CNS Drugs argues that seletracetam, an unapproved SV2A-targeting antiseizure drug, may deserve renewed development as a low-volume intranasal non-benzodiazepine rescue treatment for acute repetitive seizures. Key Findings SV2A racetam: Seletracetam is a second-generation racetam related to levetiracetam and brivaracetam. Phase IIa history: Oral seletracetam reached early clinical trials but was …
TL;DR: A 2026 medRxiv preprint introduced a 68-component NeuroMark template for single photon emission computed tomography (SPECT), a brain blood-flow imaging method, and found schizophrenia-related differences in cerebellar, subcortical, higher-cognition, visual, and triple-network perfusion patterns. Key Findings Template build: Researchers used blind independent component analysis on two large SPECT datasets of 5,001 and 5,000 scans …
TL;DR: A 2026 systematic review and meta-analysis in BMC Psychiatry reported that olanzapine produced a numerically higher body mass index gain in anorexia nervosa trials, but the pooled randomized evidence remained small, heterogeneous, and not statistically significant. Key Findings 7 RCTs included: The review found 7 randomized controlled trials with 152 people treated for anorexia …
TL;DR: A 2026 study in Cell & Bioscience found that poly-GR, a toxic repeat protein linked to C9orf72-ALS, pushed motor neuron-like cells toward ferroptosis by raising lipid peroxidation and ferrous iron while weakening the Nrf2/Slc7a11 antioxidant pathway. Key Findings GR50 model: Researchers expressed EGFP-GR50, a 50-repeat glycine-arginine poly-GR construct, in NSC-34 motor neuron-like cells. Ferroptosis …
TL;DR: A 2026 preprint in medRxiv linked higher neighborhood deprivation to faster DNA-methylation aging in 370 healthy adults, with lifetime adversity explaining part of the association and stronger direct effects among Black participants. Key Findings Yale sample anchored the test: The cross-sectional Yale Stress Center sample included 370 adults aged 18 to 50 years without …
TL;DR: A 2026 nationwide claims study in Integrative Medicine Research found that Korean traditional medicine care without recorded acupuncture claims had the lowest modeled costs and the highest 3-year QALYs among four menopausal-disorder treatment strategies, while acupuncture and integrative-care groups appeared to include sicker, higher-utilization patients. Key Findings 32,941 women: The retrospective cohort used Korean …
