TL;DR: A 2026 review in Neuroscience & Biobehavioral Reviews found that chronic primary pain studies most consistently linked higher pain sensitivity with lower mean arterial pressure, higher cortisol, higher heart rate during recovery, and lower parasympathetic recovery. Key Findings The evidence base covered 52 studies; 37 contributed qualitative evidence and 21 had enough data for …
TL;DR: A 2026 medRxiv preprint found that soluble CD27 (sCD27), a T-cell activation marker, was elevated in a subgroup of patients with severe psychiatric disorders and was more common when autoimmune disease or abnormal cerebrospinal fluid (CSF) inflammation markers were present. Key Findings The immunopsychiatry cohort included 115 patients: Researchers compared severe psychiatric-disorder cases enriched …
TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health linked better sleep quality before influenza vaccination and earlier chronotype to stronger immune-response markers in 108 adults. Key Findings Vaccination cohort: Researchers studied sleep, vaccination timing, chronotype, and immune markers in 108 adults after influenza vaccination. Pre-shot sleep quality: Better Pittsburgh Sleep Quality Index …
TL;DR: A 2026 scoping review in Nature and Science of Sleep found that sleep bruxism and gastroesophageal reflux disease were positively associated across 7 adult human studies, but the evidence remains too heterogeneous to prove causality. Key Findings 174 records screened: Database searches in PubMed, Scopus, and Web of Science narrowed 174 references to 7 …
TL;DR: A 2026 preprint posted to medRxiv found that intermittent theta-burst transcranial temporal interference stimulation (iTBS-tTIS), a noninvasive electrical method aimed at the right putamen, lowered left-sided Parkinson’s motor scores during stimulation in 19 patients. Key Findings 19 Parkinson’s patients and 19 healthy controls completed a randomized, double-blind crossover stimulation study. MDS-UPDRS III, the motor …
TL;DR: A 2026 medRxiv preprint found that older adults with Montreal Cognitive Assessment (MoCA)-defined mild cognitive impairment had less coordinated pulse-wave responses during a cognitive challenge than cognitively intact older adults. Key Findings Community cognitive-aging sample: The southern Taiwan dataset included 101 older adults: 12 reference participants, 50 people in a MoCA-defined mild cognitive impairment …
TL;DR: A 2026 Molecular Psychiatry ENIGMA mega-analysis found that medication status in bipolar disorder was linked to subtle differences in subcortical brain volume, with antiepileptic and antipsychotic exposure most consistently tied to smaller hippocampal and thalamic volumes. Key Findings 6,729-person ENIGMA sample: Researchers pooled MRI data from 2,664 people with bipolar disorder and 4,065 controls …
TL;DR: A 2026 cross-sectional study in Nature and Science of Sleep linked second-trimester sleep disturbance, measured with the Pittsburgh Sleep Quality Index (PSQI), to depressive symptoms, vomiting, diet quality, and several birth-outcome patterns in 2,210 pregnant women in Wuhan, China. Key Findings Sleep disturbance affected 18.14%: 401 of 2,210 pregnant women had PSQI scores above …
TL;DR: A 2026 study in Advanced Science found that flexible polyimide brain-implant probes produced lower long-term tissue reactivity than stiff silicon electrodes, while thinner probe designs and skull-detached mounting mattered less than the implant material itself. Key Findings Material mattered most: Flexible polyimide probes triggered less brain-tissue reactivity than stiff silicon electrodes. Not reaction-free: Polyimide …
TL;DR: A 2026 study in Clinical Case Reports described persistent genital arousal disorder in a woman in her 30s, with symptom improvement after combined risperidone, sodium valproate, fluoxetine, short-term clonazepam, relaxation work, and cognitive behavioral strategies. Key Findings Five-month symptom course: The patient reported spontaneous genital tingling, throbbing, and warmth without sexual desire or fantasy. …
