Brain Injury

Chemotherapy Neuropathy Review Links Pain to Brain Changes

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Chemotherapy Neuropathy Review Links Pain to Brain Changes

TL;DR: A 2026 review in Reviews in the Neurosciences argues that chemotherapy-induced peripheral neurotoxicity (CIPN), nerve injury from cancer treatment, can involve central nervous system changes that help explain chronic neuropathic pain and chemotherapy-related cognitive impairment. Key Findings 70-80% during treatment: The review cites chemotherapy-induced peripheral neurotoxicity as affecting about 70-80% of patients during treatment. …

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EPA Impaired Brain Vessel Repair After Repetitive Brain Injury (CTE)

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EPA Rewired Brain Vessels After Repetitive Brain Injury

EPA Rewired Brain Vessels After Repetitive Brain Injury TL;DR: Fish-oil-derived EPA looked less like a simple neuroprotective supplement and more like a lipid signal that changed brain-vessel repair after repetitive mild traumatic brain injury. Key Findings EPA accumulated before injury: In a fish-oil diet model, eicosapentaenoic acid built up in the brain at baseline rather …

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Ethylene Oxide Levels Increase Stroke Risk in Young Adults in the U.S. (2024 Study)

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Higher ethylene oxide (EtO) exposure is significantly associated with an increased risk of stroke in U.S. adults, particularly those under 50 years old. Highlights: Higher levels of EtO are linked to increased stroke rates, with individuals in the top 25% of exposure showing a stroke prevalence 1.6 times higher than those in the bottom 25%. …

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Nanoparticle Enhanced Radiotherapy (NERT) for Brain Tumor Treatment (2024 Research)

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Nanoparticle-enhanced radiotherapy (NERT) is a promising approach to improving brain tumor treatment by enhancing radiotherapy efficacy through targeted delivery and radiosensitization while overcoming challenges posed by the blood-brain barrier. Highlights: Mechanisms of Action: NERT utilizes nanoparticles (NPs) as radiosensitizers, enhancing radiation-induced damage through physical dose enhancement and biological/chemical sensitization. Types of Nanoparticles: Various NP types, …

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Lithium Appears Neuroprotective in Traumatic Brain Injury (TBI) (2024 Research)

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Lithium shows promise in treating traumatic brain injury (TBI) by mitigating neuroinflammation, protecting against neuronal damage, and improving cognitive functions. Highlights: Neuroprotective Mechanisms: Lithium’s therapeutic effects involve complex molecular mechanisms including gene expression, neurotransmitter signaling, and circadian modulation, contributing to neuronal protection and recovery post-TBI. Targeted Brain Regions: Post-treatment, lithium concentrations are notably higher in …

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Selegiline Reverses Anxiety & Memory Impairment in Amyloid Beta-Induced Alzheimers Model Rats (2024 Study)

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The study demonstrated that selegiline (SEL) improves memory performance, reduces anxiety, and modulates oxidative stress in an Alzheimer’s disease (AD) rat model. Highlights: Memory Improvements: SEL administration improved recognition memory, spatial memory, and passive avoidance memory in AD rats. Anxiety Reduction: SEL significantly reduced anxiety-like behavior in AD rats, as evidenced by performance in the …

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Repurposing Antipsychotics & Antidepressants to Treat Glioblastoma (2024 Study)

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Repurposing antipsychotics and antidepressants with favorable safety profiles and blood-brain barrier permeability shows promise for glioblastoma (GBM) treatment, primarily through disrupting lysosomal function and inducing cell death. Highlights: Mechanism of Action: The studied antipsychotics and antidepressants induce GBM cell death by disrupting lysosomal function, leading to lysosomal membrane rupture. PTEN Sensitivity: GBMs with intact PTEN …

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Type 2 Diabetes Linked to Lower Cerebral Blood Flow (CBF) in Hippocampus (2024 Study)

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This study shows that type 2 diabetes causes decreased blood flow and changes in neural activity in specific parts of the hippocampus, which may initially compensate for cognitive decline but deteriorate with worsening diabetes. Highlights: Decreased Perfusion: Patients with type 2 diabetes have lower blood flow in the right hippocampal CA1, DG, and subiculum areas. …

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1-Year Post-COVID Neuropsychiatric Symptoms: Fatigue, Cognition, Anxiety, Depression, Headache, Dizziness (2024 Study)

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A study found that adults recovering from their first COVID-19 infection more than 1-year ago have higher levels of fatigue and other chronic neuropsychiatric symptoms, influenced by vaccination status and socioeconomic factors. Highlights: Adults who had their first COVID-19 infection over 1-year ago reported significantly higher fatigue levels compared to those who never had COVID-19 …

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BPC-157 Peptide May Treat CNS Disorders: Stroke, Schizophrenia, Spinal Cord Injury

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The naturally occurring peptide BPC 157 shows potential to treat stroke, schizophrenia symptoms, and spinal cord injury in animal models. Key facts: BPC 157 rapidly counteracted stroke damage and led to full recovery of memory, coordination and movement in rats. The peptide alleviated schizophrenia-like symptoms and catalepsy in rodent models by modulating dopamine, glutamate and …

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