Neuropsychiatric Disorders

Schizophrenia Gut Microbiome Review Found Composition Shifts, Not Richness Loss

July 1, 2026 by BrainASAP

TL;DR: A 2026 systematic review and meta-analysis in International Journal of Molecular Sciences found no significant global gut-microbiome alpha-diversity difference in schizophrenia, but reported recurring community-composition and taxonomic shifts. Key Findings 48 studies: The review included 48 human observational studies published between 2017 and 2025. 14 meta-analyzed studies: Only 14 studies provided enough data for …

Schizophrenia MRI Study Found Cortical Network Subtypes

July 1, 2026 by BrainASAP

TL;DR: A 2026 preprint on medRxiv used multisite MRI data from 3,958 people with schizophrenia and 5,489 controls to map cortical network disruptions and identify two robust brain-structure subtypes. Key Findings 9,447 MRI participants: The analysis included 3,958 individuals with schizophrenia and 5,489 neurotypical controls from 40 centers. Gradient alterations: Schizophrenia was linked with widespread …

Resting Facial Expressions Differed in Older Adults With MCI-Level Scores

July 1, 2026 by BrainASAP

TL;DR: A 2026 preprint on medRxiv found that older adults with mild-cognitive-impairment-level scores showed different resting facial action patterns than healthy controls, especially upper lip raiser, lip tightener, and lip suck measures. Key Findings MCI-level comparison: The study included 45 older adults and compared 31 participants in the MCI-level group with 14 healthy controls. MoCA-defined …

Parkinson’s Prevention Review Highlights Exercise, Diet, Toxins, and Rehabilitation

June 30, 2026 by BrainASAP

TL;DR: A 2026 narrative review in Neurological Research and Practice argued that Parkinson’s prevention is most actionable through physical activity, Mediterranean-style diet patterns, toxin reduction, earlier prodromal detection, and better rehabilitation after diagnosis. Key Findings Fastest-growing neurological disorder: The review described Parkinson’s disease as the fastest-growing neurological disorder worldwide. 6.2 to 11.8 million cases: A …

Treatment-Resistant Depression Affected 34% in Pakistan DIVERGE Study

June 30, 2026 by BrainASAP

TL;DR: A 2026 preprint in medRxiv found that treatment-resistant depression affected 34% of medication-exposed major-depression patients in Pakistan’s DIVERGE study, with social support and CYP2C19 metabolizer status standing out as locally important treatment-response markers. Key Findings 3,677 eligible patients: The treatment-resistance analysis included adults with major depressive disorder who had medication exposure and enough adherence …

P2X7 Receptors May Link Neuroinflammation to Depression Biology

June 30, 2026 by BrainASAP

TL;DR: A 2026 review in Purinergic Signalling argues that ATP-gated P2X receptors, especially P2X7 and P2X4, may connect stress-related neuroinflammation with depression and bipolar-disorder biology. Key Findings P2X7 focus: The review describes P2X7 receptor signaling as a major link between stress, microglial activation, NLRP3 inflammasome signaling, cytokine release, and lower neuroplasticity. P2X4 context: P2X4 receptors …

Olanzapine Anorexia Nervosa Trials Showed Uncertain BMI Gain

June 30, 2026 by BrainASAP

TL;DR: A 2026 systematic review and meta-analysis in BMC Psychiatry reported that olanzapine produced a numerically higher body mass index gain in anorexia nervosa trials, but the pooled randomized evidence remained small, heterogeneous, and not statistically significant. Key Findings 7 RCTs included: The review found 7 randomized controlled trials with 152 people treated for anorexia …

Neighborhood Deprivation Linked to Faster Epigenetic Aging via Adversity

June 30, 2026 by BrainASAP

TL;DR: A 2026 preprint in medRxiv linked higher neighborhood deprivation to faster DNA-methylation aging in 370 healthy adults, with lifetime adversity explaining part of the association and stronger direct effects among Black participants. Key Findings Yale sample anchored the test: The cross-sectional Yale Stress Center sample included 370 adults aged 18 to 50 years without …

TKM Without Acupuncture Claims Had Best Menopause Depression Cost-Utility Result

June 30, 2026 by BrainASAP

TL;DR: A 2026 nationwide claims study in Integrative Medicine Research found that Korean traditional medicine care without recorded acupuncture claims had the lowest modeled costs and the highest 3-year QALYs among four menopausal-disorder treatment strategies, while acupuncture and integrative-care groups appeared to include sicker, higher-utilization patients. Key Findings 32,941 women: The retrospective cohort used Korean …

AI-Guided Variable Levodopa Feasible in 5 Parkinson’s Patients

June 30, 2026 by BrainASAP

TL;DR: A 2026 open-label feasibility trial in IBRO Neuroscience Reports tested an AI-guided variable levodopa schedule in 5 people with Parkinson’s disease and found 4 patients improved on UPDRS, but the study was far too small and uncontrolled to prove efficacy. Key Findings Feasibility sample: The single-center trial enrolled 5 people with Parkinson’s disease after …

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