Neuropsychiatric Disorders

rTMS Improves Blood Biomarkers (BDNF, GDNF, Thiol, S100B) in Depression (2024 Study)

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Repetitive transcranial magnetic stimulation (rTMS) therapy improves key biochemical markers in major depressive disorder (MDD) patients, indicating its effectiveness as an antidepressant treatment. Highlights: Improved Antioxidant Levels: rTMS therapy significantly increased total antioxidant status (TAS), total thiol (TT), and native thiol (NT) levels in MDD patients compared to their levels before treatment. Reduced Oxidative Stress: …

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8 Plasma Biomarkers to Predict Parkinson’s Disease Up to 7 Years Before Motor Symptoms (2024 Study)

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A study identified a panel of eight plasma biomarkers that can predict Parkinson’s disease up to seven years before motor symptoms appear. Highlights: Biomarker Panel: The study validated a panel of 8 proteins, including Granulin precursor and Complement C3, using mass spectrometry, which can differentiate Parkinson’s patients from healthy controls and identify pre-motor individuals with …

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Noise-Induced Hearing Loss (NIHL) & White Matter Microstructure Changes in the Brain (2024 Study)

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TLDR: Patients with noise-induced hearing loss (NIHL) exhibit significant changes in the white matter (WM) microstructure of their brains, particularly affecting the auditory and language pathways. Highlights: A study compared 122 patients with varying degrees of NIHL and 84 healthy controls. Diffusion tensor imaging (DTI) revealed significant differences in the white matter microstructure, particularly in …

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Low Vitamin D Increases Stroke Risk & Worsens Post-Stroke Prognosis (2024 Meta-Analysis)

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TLDR: Lower serum vitamin D levels are associated with an increased risk of stroke, particularly ischemic stroke, and are linked to poorer stroke outcomes. Highlights: The meta-analysis included 27 studies with 45,302 participants, finding a combined relative risk (RR) of 1.28 for stroke risk associated with low vitamin D levels. A lower level of serum …

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Depression Linked to Increased Risk of Knee Osteoarthritis (2024 Study)

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TLDR: A study found a bidirectional causal relationship between depression and osteoarthritis (OA) but only a one-way relationship where depression increases the risk of knee osteoarthritis (KOA). Highlights: Bidirectional Causality: There is a bidirectional causal relationship between depression and osteoarthritis (OA), meaning depression can increase the risk of OA and vice versa. Knee Osteoarthritis (KOA): …

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Herpes Zoster Vaccination Linked to Lower Dementia Risk (2024 Meta-Analysis)

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TLDR: Herpes zoster vaccination is linked to a lower risk of dementia, but more studies are needed to confirm this association. Highlights: Five high-quality studies involving 103,615 vaccinated patients were analyzed. Herpes zoster vaccination was associated with a reduced risk of dementia (pooled odds ratio: 0.84). High variability among studies was observed, necessitating a random …

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Gut Bacteria Abnormalities in Parkinson’s Disease: Global Analysis (2024)

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TLDR: A study identified specific gut microbial features in Parkinson’s disease (PD) across different countries, highlighting increased α-diversity, altered bacterial species, and decreased metabolites in PD patients. Highlights: Increased α-Diversity: The study found higher α-diversity in PD patients across six datasets from different countries. Altered Bacterial Species: Species such as Akkermansia muciniphila were increased, while …

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GLP-1 Receptor Agonists & Lower Dementia Risk in Older Adults with Diabetes (2024 Study)

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TLDR: GLP-1 agonists were found to significantly reduce the risk of dementia in older individuals with type 2 diabetes mellitus (T2DM) compared to DPP-4 inhibitors and sulfonylureas. Highlights: A sequential trial emulation was conducted using data from Swedish national registers from 2010 to 2020, involving 88,381 participants aged 65 or older with T2DM. The incidence …

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Peptide PHDP5 May Reverse Cognitive Impairment in Alzheimers Disease (2024 Research)

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TLDR: Researchers demonstrated that intranasal administration of the peptide FITC-PHDP5-CPP reverses early cognitive impairment in Alzheimer’s disease (AD) model mice, showing potential as a treatment for AD-associated cognitive decline. Highlights: PHDP5, derived from the pleckstrin homology domain of dynamin 1, inhibits the interaction between dynamin and microtubules, rescuing synaptic dysfunction caused by tau accumulation. The …

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High Salt Intake Linked to Alzheimers Disease & Dementia Risk in Europeans (2024 Study)

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TLDR: This study provides evidence that high salt intake is causally associated with an increased risk of developing dementia, including Alzheimer’s disease (AD) and undefined dementia. Highlights: Causal Association: High salt intake is significantly associated with an increased risk of any dementia (OR = 1.73) and specifically Alzheimer’s disease (OR = 2.10). Cognitive Performance: Higher …

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