Neuropsychiatric Disorders

Early-Life Adversity Screening Poorly Predicted Adult Mental Health Risk

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Early-Life Adversity Screening Poorly Predicted Adult Mental Health Risk

TL;DR: A 2026 population-based study in The Canadian Journal of Psychiatry found that early-life adversity scores were linked to higher group-level mental health risk but performed poorly for identifying which Canadian adults had anxiety, mood disorders, substance use disorders, or suicidality. Key Findings 7,608 Canadian adults: Researchers analyzed nationally representative 2022 survey data collected during …

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Parenteral Clomipramine Showed No Clear Advantage Over Oral Clomipramine

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Parenteral Clomipramine Showed No Clear Advantage Over Oral Clomipramine

TL;DR: A 2026 systematic review and meta-analysis in Acta Neuropsychiatrica found no clear evidence that parenteral clomipramine is better than oral clomipramine for depression or obsessive-compulsive disorder, with low or very low certainty across the main randomized-trial evidence. Key Findings 4,973 publications screened: The review identified 14 randomized controlled trials relevant to parenteral clomipramine in …

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Suicidal Ideation Was the Central Symptom Hub for Palestinian Refugees in Egypt; Secondary Hubs Differed by Sex

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Suicidal Ideation Was the Central Symptom Hub for Palestinian Refugees in Egypt; Secondary Hubs Differed by Sex

TL;DR: A 2026 cross-sectional study in Psychiatry Research surveyed 558 Palestinian refugees displaced to Egypt after the 2023 Gaza war and used Bayesian network analysis to map their psychological symptoms; suicidal ideation emerged as the central hub for both men and women, with secondary core symptoms differing by gender (loss of energy in men, psychomotor …

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Online Mindfulness Therapy Reduced Cancer Distress for 9 Months

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Online Mindfulness Therapy Reduced Cancer Distress for 9 Months

TL;DR: A 2026 secondary randomized-trial analysis in Journal of Medical Internet Research found that both online MBCT formats reduced psychological distress and improved well-being through 9 months, while people with fewer psychological resources appeared to gain larger benefits. Key Findings Study type: a long-term follow-up of two online mindfulness-based cognitive therapy formats for people with …

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Neuroticism Linked to Problem-Focused Thoughts During Blank-Screen Rest

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Neuroticism Linked to Problem-Focused Thoughts During Blank-Screen Rest

TL;DR: A 2026 study in Personality and Individual Differences found that people higher in neuroticism reported more problem- and uncertainty-focused thoughts during blank-screen rest periods, which tracked with more unpleasant feelings. Key Findings Neuroticism was tested during idle thought: researchers used a blank-screen paradigm to sample what participants thought about when they had no task …

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Serum LC-MS/MS Screen Detected 77 Neuropsychiatric Drugs

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Serum LC-MS/MS Screen Detected 77 Neuropsychiatric Drugs

TL;DR: A 2026 study in Drug Design, Development and Therapy validated liquid chromatography-tandem mass spectrometry (LC-MS/MS), a high-specificity lab method, to screen serum for 77 neuropsychiatric drugs and then applied it to 1,021 clinical specimens over 3 years. Key Findings 77 drugs screened: Researchers developed a serum LC-MS/MS method for simultaneous qualitative identification of neuropsychiatric …

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Naltrexone/Bupropion Reduced Calories in Binge-Eating Disorder Lab Study

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Naltrexone/Bupropion Reduced Calories in Binge-Eating Disorder Lab Study

TL;DR: A 2026 human laboratory study in Drug and Alcohol Dependence Reports found that naltrexone/bupropion did not change whether people with binge-eating disorder started eating preferred snacks, but it reduced how many calories they ate once they began. Key Findings Naltrexone/bupropion trial included 50 adults: Participants came from a randomized trial of naltrexone/bupropion, including 23 …

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Six Weeks of Group Songwriting Reduced Paranoia and Shifted Pronoun Use in 20 Adults With Psychosis

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Six Weeks of Group Songwriting Reduced Paranoia and Shifted Pronoun Use in 20 Adults With Psychosis

TL;DR: A 2026 longitudinal pilot study in Psychosis from Yale recruited 20 adults with schizophrenia or distressing auditory hallucinations into 6 weeks of group songwriting and found reduced paranoia in less-severely affected participants plus a shift from self-focused first-person pronouns toward plural pronouns. Key Findings Group songwriting recruited adults with psychosis symptoms: 20 participants aged …

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MRI Brain Charts Predicted 10-Year Psychosis Outcomes

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MRI Brain Charts Predicted 10-Year Psychosis Outcomes

TL;DR: A 2026 study in The British Journal of Psychiatry found that in first-episode psychosis, MRI deviations from age-matched brain norms at illness onset helped predict which patients would carry heavier symptom burdens and poorer functioning for years afterward. Key Findings 100,000-scan reference model: Researchers used a lifespan normative MRI model built on more than …

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PTP1B Inhibition Reduced Amyloid-Beta in Alzheimer’s Mice

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PTP1B Inhibition Reduced Amyloid-Beta in Alzheimer's Mice

TL;DR: A 2026 mouse study in Proceedings of the National Academy of Sciences found that deleting or inhibiting PTP1B improved memory behavior, reduced amyloid-beta burden, and pushed microglia toward an amyloid-clearing state. Key Findings Memory behavior improved: APP/PS1 mice lacking PTP1B performed better in novel object recognition and Morris water maze tests; the PTP1B inhibitor …

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