TL;DR: A 2026 preprint in medRxiv reported that an interpretable CatBoost machine-learning model predicted stroke-associated pneumonia after acute ischemic stroke bridging therapy with a test-set AUC of 0.932, with 7-day stroke severity and early inflammatory markers among the strongest contributors. Key Findings 135 stroke patients: The retrospective analysis included 135 acute ischemic stroke patients who …
TL;DR: A 2026 study in Glia used human single-nucleus RNA sequencing datasets and mouse validation to identify a shared neurodegeneration-linked microglial transcription program, highlighting SPP1 as a disease-associated microglia marker. Key Findings Five disease contexts: The analysis integrated human microglia datasets from Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, frontotemporal dementia, and aging. Single-nucleus RNA-seq: …
TL;DR: A 2026 systematic review in Cognitive, Affective, & Behavioral Neuroscience found that stroke and traumatic brain injury populations showed consistent social cognition alterations across domains, while insula, cingulate cortex, middle frontal gyrus, and corpus callosum were repeatedly implicated. Key Findings Study type: a PRISMA-guided systematic review of social cognition domains after stroke and traumatic …
TL;DR: A 2026 uncontrolled pilot study in BJPsych Open found that SMART, a personalized text-message program for metabolic health in people with schizophrenia spectrum disorders, improved patient activation, diabetes self-management confidence, health literacy, and recovery scores over 12 weeks, while objective cardiometabolic markers did not significantly change. Key Findings SMART reached a schizophrenia-risk group: Researchers …
TL;DR: A 2026 mouse study in Nature mapped more than 76,000 single-neuron projections from the orofacial motor cortex (OMC) and found that Alston’s singing mouse, which produces audible song, has 2.8-fold higher OMC connectivity to an auditory cortical region and 3.3-fold higher OMC connectivity to the midbrain periaqueductal grey (PAG) than the laboratory mouse. Key …
TL;DR: A 2026 preprint in medRxiv reported that serum myelin oligodendrocyte glycoprotein (MOG) protein was higher in multiple sclerosis than controls and higher during clinical relapse than remission. Key Findings 20.5 pg/ml higher: Serum MOG protein was higher in MS than healthy donors by a mean difference of 20.5 pg/ml. 27.5 pg/ml higher: MS samples …
TL;DR: A 2026 study in PNAS from Oregon Health & Science University and Anhui University used optogenetics in mice to map a specific serotonin-producing brain circuit that runs straight to the auditory system, showed that activating this circuit produced tinnitus-like behavior, and traced a likely mechanism for why some patients on SSRI antidepressants report worsened …
TL;DR: A 2026 preprint in medRxiv reported that SenseCheQ, a home quantitative sensory testing device, produced reliable vibration and temperature-threshold measurements in 30 healthy adults and tracked early sensory changes in 3 breast cancer patients receiving neurotoxic chemotherapy. Key Findings 30-person home study: Healthy adults completed one familiarization session and three self-administered home sessions using …
TL;DR: A 2026 birth cohort study in Environment & Health linked low-level prenatal lead exposure to lower infant Ages and Stages Questionnaire (ASQ-3) developmental scores, with FAM50B/PTCHD3 DNA methylation markers explaining part of the association. Key Findings Lead was the clearest metal finding: Among 21 detectable cord-blood metals, lead showed a consistent negative association with …
TL;DR: A 2026 study in Journal of Pain Research described 3 adults with type I complex regional pain syndrome (CRPS), a severe neuropathic pain condition with sensory, autonomic, motor, and skin changes, whose pain scores improved after pregabalin and who were then able to participate more fully in rehabilitation. Key Findings Case-series evidence: Researchers reported …
