Glioblastoma Long-Read Single-Cell Sequencing Found Tumor-Specific Isoforms

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Glioblastoma Long-Read Single-Cell Sequencing Found Tumor-Specific Isoforms

TL;DR: A 2026 Nature Communications study used long-read single-cell RNA sequencing to map full-length isoforms in glioblastoma and found tumor-specific transcripts that short-read methods often miss. Key Findings 27 GBM samples: Researchers profiled histologically confirmed IDH-wildtype glioblastoma samples using matched short-read and long-read single-cell sequencing. 100 million reads: The optimized long-read workflow produced a median …

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rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

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rTMS Plus Risperidone Improved Schizophrenia Cognitive and Aggression Scores

TL;DR: A 2026 randomized controlled study in Pakistan Journal of Pharmaceutical Sciences found that adding 20 Hz repetitive transcranial magnetic stimulation (rTMS) to risperidone was linked with lower cognitive-factor and aggression scores after 4 weeks in schizophrenia patients. Key Findings Schizophrenia trial sample: The single-center trial randomized 80 patients, with 40 assigned to risperidone alone …

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GPR3 Linked CREB Signaling to Presynaptic Maturation

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GPR3 Linked CREB Signaling to Presynaptic Maturation

TL;DR: A 2026 cellular neuroscience study in iScience found that GPR3, a constitutively active G-protein-coupled receptor, behaved like an immediate-early gene and helped connect CREB signaling to presynaptic maturation during neuronal differentiation. Key Findings Biphasic GPR3 induction: Gpr3 rose quickly after nerve growth factor stimulation, dipped, then increased again during later neuronal differentiation. NET-CAGE promoter …

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GLP-1 Agonists Reduced Fat Mass With Modest Lean-Mass Loss

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GLP-1 Agonists Reduced Fat Mass With Modest Lean-Mass Loss

TL;DR: A 2026 systematic review and meta-analysis in International Journal of Obesity found that glucagon-like peptide-1 receptor agonists, metabolic drugs that extend a satiety and glucose-control hormone pathway, reduced body weight mainly through fat loss while lean-mass reductions were generally modest. Key Findings 36 studies reviewed: Researchers included 36 studies in the qualitative review and …

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Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

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Depression and Alcohol Polygenic Scores Improved Comorbidity Prediction

TL;DR: A 2026 study in Behavior Genetics found that combining major depressive disorder and alcohol use disorder polygenic scores improved prediction of their comorbidity in 7,965 Add Health participants, but added little for either condition alone. Key Findings Add Health dataset anchored the analysis: The study used 7,965 European, African, and Admixed American ancestry participants …

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Brief Yoga Raised Heart Rate but Not Cortisol in Stress Pilot

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Brief Yoga Raised Heart Rate but Not Cortisol in Stress Pilot

TL;DR: A 2026 randomized pilot study in JMIR Formative Research found that one brief yoga session did not significantly change salivary cortisol compared with quiet sitting, but it did raise heart rate during the active movement phase. Key Findings Yoga pilot sample: The pilot randomized 19 adults, with 10 participants assigned to a 24-minute yoga …

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Brain-Derived p-tau217% Better Classified Alzheimer Pathology

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Brain-Derived p-tau217% Better Classified Alzheimer Pathology

TL;DR: A 2026 preprint in medRxiv found that brain-derived p-tau217%, a blood marker designed to isolate central nervous system tau, classified Alzheimer disease pathology better than standard plasma p-tau217 in several Alzheimer cohorts. Key Findings CNS-selective ratio: The proposed marker, brain-derived p-tau217%, estimates the share of circulating tau that is both brain-derived and phosphorylated at …

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Body Dysmorphic Disorder Symptoms Correlated With Perfectionism

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Body Dysmorphic Disorder Symptoms Correlated With Perfectionism

TL;DR: A 2026 meta-analysis in BMC Psychiatry found a moderate cross-sectional association between body dysmorphic disorder symptoms and perfectionism across 34 studies and 13,107 participants. Key Findings 34-study meta-analysis: The review pooled 34 studies with a total of 13,107 participants. Moderate main association: Body dysmorphic disorder symptoms correlated with perfectionism at r = .32, 95% …

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Betrayal Biased Social Inference Through Selective Observation

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Betrayal Biased Social Inference Through Selective Observation

TL;DR: A 2026 study in PLOS Computational Biology found that people overestimated an opponent’s competitiveness after betrayal, especially when they chose to watch the opponent instead of controlling their own avatar. Key Findings 62-person social task: 62 adults played a 2D prey-pursuit game with a computerized opponent whose hidden friendliness changed over time. Betrayal shifted …

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Astrocyte Glucocorticoid Receptor Signaling Restricted Visual Cortex Plasticity

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Astrocyte Glucocorticoid Receptor Signaling Restricted Visual Cortex Plasticity

TL;DR: A 2026 mouse study in Nature found that the astrocyte glucocorticoid receptor pathway helped mature visual cortex circuitry and restricted ocular dominance plasticity, linking light exposure, stress-hormone input, and astrocyte-driven circuit closure. Key Findings 70,907 cells profiled: SHARE-seq mapped RNA expression and chromatin accessibility across visual cortex development in normal-reared and dark-reared mice. Five …

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