TL;DR: A 2026 study in NEJM Evidence found that solriamfetol added 9.4 minutes of objective wakefulness in early-morning shift work disorder after 4 weeks, without a higher overall adverse-event rate than placebo. Key Findings 78 early-morning workers: Participants had excessive sleepiness linked to shifts starting between 3 a.m. and 7 a.m. Randomized double-blind design: The …
TL;DR: A 2026 rat study in Neuropsychopharmacology found that chemogenetically inhibiting a prelimbic cortex to nucleus accumbens core pathway blocked cue-triggered cocaine seeking after cocaine alone, but did not block relapse-like behavior after sequential cocaine and alcohol use. Key Findings The model tested sequential polysubstance use: rats self-administered cocaine, then some received access to 20% …
TL;DR: A 2026 study in Journal of Clinical Sleep Medicine found that in 65 continuous positive airway pressure (CPAP) adherent patients with obstructive sleep apnea, those who still showed objective daytime sleepiness on a psychomotor vigilance task scored worse on global cognition, memory, executive function, attention, and processing speed despite using their devices regularly. Key …
TL;DR: A 2026 preprint in medRxiv trained machine-learning models on Danish electronic health records and found that an XGBoost model predicted clozapine initiation within 365 days with an AUROC of 0.81 in patients with schizophrenia or schizoaffective disorder. Key Findings 229,761 prediction times: The main model used routine psychiatric hospital contacts from 5,806 patients after …
TL;DR: A 2026 study in O&G Open found that cannabis exposure 2–7 years after a first pregnancy was not associated with incident hypertension after adjustment in the nuMoM2b Heart Health Study. Key Findings No adjusted hypertension association: Cannabis exposure was not associated with incident hypertension after adjustment (AOR 1.05; 95% CI, 0.63-1.76). 4,079-person analysis: Researchers …
TL;DR: A 2026 study in Cell Chemical Biology found that alzheimer’s inflammation may be driven by a specific chemical switch: S-nitrosylation of STING at cysteine 148, which pushed innate immune signaling toward synaptic damage. Key Findings STING carried the redox switch: The study identified S-nitrosylation of human STING at cysteine 148 as a redox modification …
TL;DR: A 2026 study in The British Journal of Psychiatry found that people with anxiety disorders showed hyper-scanning during neutral image viewing and hyper-pursuit during moving-dot tracking, suggesting that eye-tracking could capture measurable patterns of anxiety-related vigilance. Key Findings 307-person sample: Researchers compared 91 patients with anxiety disorders, 118 with depressive disorders, and 98 healthy …
TL;DR: A 2026 in vitro study in Molecular and Clinical Oncology found that amitriptyline reduced C6 glioma cell viability and PD-L1 checkpoint expression, but the same drug weakened the cell-killing effect of radiation when combined with temozolomide. Key Findings Amitriptyline alone reduced glioma cell growth: In non-radiated C6 glioma cultures, 10 micromolar amitriptyline lowered viability …
TL;DR: A 2026 randomized feasibility trial in JMIR Mental Health found both a structured AI therapy chatbot and ChatGPT reduced PHQ-9 depression scores versus assessment-only control, but neither AI condition improved anxiety significantly or beat the other. Key Findings PHQ-9 depression scores fell: The Patient Health Questionnaire-9 (PHQ-9), a depression-symptom scale, improved more with AI …
TL;DR: A 2026 systematic review and meta-analysis in Drug and Alcohol Review estimated high adolescent substance-use exposure in South Africa, with lifetime alcohol use at 35.09%, tobacco at 25.47%, and cannabis at 10.47% across community and school-based studies. Key Findings 30 publications were included: Researchers synthesized 202 prevalence estimates from South African adolescent samples. Total …
