Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

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Natural Daylight During Office Hours Improved Glucose Time-in-Range and Shifted Substrate Metabolism in Type 2 Diabetes

TL;DR: A 2026 randomized crossover trial in Cell Metabolism compared natural daylight against standard artificial office lighting in 13 older adults with well-controlled type 2 diabetes and found that natural-daylight days produced more time in a healthy blood-glucose range (about 51% vs 43%), smaller glucose swings, and a metabolic shift toward burning more fat and …

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Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

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Three or More Live Births Was the Only Reproductive Factor Linked to Lower Stroke Risk in Framingham Women

TL;DR: A 2026 study in the Journal of the American Heart Association followed 1,882 stroke-free women from the Framingham Heart Study for a median of 18 years and found that having three or more live births was associated with a reduced risk of clinical stroke and lower MRI markers of vascular brain injury — the …

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Lower-Body Cues Matched Whole-Body Accuracy in Female Body Size Judgments

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Lower-Body Cues Matched Whole-Body Accuracy in Female Body Size Judgments

TL;DR: A 2025 study in BMC Biology found that people judged female body size about as accurately from lower-body images as from whole-body images, but isolated thigh regions alone were not enough. Key Findings Two body-perception experiments: Researchers tested 99 participants in Experiment 1 and 116 participants in Experiment 2 using a bodyline task. Lower-body …

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IQ at Age 23 Predicted Socioeconomic Status at Age 27, With Genes Explaining 69-98% of the Link in TwinLife Germany

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IQ at Age 23 Predicted Socioeconomic Status at Age 27, With Genes Explaining 69-98% of the Link in TwinLife Germany

TL;DR: A 2026 study in Scientific Reports used the German TwinLife panel (228 monozygotic and 212 same-sex dizygotic twin pairs) to show that intelligence quotient (IQ) at age 23 predicted four socioeconomic status (SES) outcomes at age 27, with genetic factors explaining 69-98% of the IQ-SES association. Key Findings IQ at age 23 predicted SES …

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Acute and Post-Acute Settings Initiated Most Cognition-Altering Prescriptions in Older Adults With Dementia

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Acute and Post-Acute Settings Initiated Most Cognition-Altering Prescriptions in Older Adults With Dementia

TL;DR: A 2026 study in JAMA Network Open analyzed Medicare claims for adults 66+ from 2008 to 2021 and found that cognition-altering medications — antipsychotics, benzodiazepines, hypnotics, anticholinergics — were disproportionately initiated in emergency rooms, hospitals, and skilled nursing facilities rather than doctors’ offices, especially in dementia patients (43% of antipsychotic starts vs 22% of …

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Cochrane Review of 17 Trials Found Anti-Amyloid Antibodies Made No Clinically Meaningful Difference in Early Alzheimer’s

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Cochrane Review of 17 Trials Found Anti-Amyloid Antibodies Made No Clinically Meaningful Difference in Early Alzheimer's

TL;DR: A 2026 systematic review in The Cochrane Database of Systematic Reviews pooled 17 trials of anti-amyloid monoclonal antibodies (N=20,342 people with mild cognitive impairment or mild Alzheimer’s dementia) and concluded that any effect on memory decline or dementia severity was either nonexistent or well below the threshold considered clinically meaningful for patients. Key Findings …

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Children and Adolescents With ADHD Had Roughly 6x the Depression Rate of Peers in 24-Study Meta-Analysis

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Children and Adolescents With ADHD Had Roughly 6x the Depression Rate of Peers in 24-Study Meta-Analysis

TL;DR: A 2025 meta-analysis in the Journal of Attention Disorders pooled 24 studies (N=6,815) and estimated that 11.31% of children and adolescents with ADHD had co-occurring depression — about six times the rate seen in neurotypical peers in head-to-head case-control studies (~12% vs ~2%). Key Findings Pooled depression rate of 11.31% across 24 studies: The …

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Mendelian Randomization Found Brain Structure Causally Contributed to ADHD and Autism

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Mendelian Randomization Found Brain Structure Causally Contributed to ADHD and Autism

TL;DR: A 2026 Mendelian randomization study in Progress in Neuro-Psychopharmacology & Biological Psychiatry used genetic data to test direction of effect between brain structure and neurodevelopmental conditions, and found that increased surface area in the superior frontal gyrus raised ADHD risk while increased surface area in the orbital frontal gyrus protected against autism — with …

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Language and Theory of Mind Brain Systems Were Already Distinct in 3- to 9-Year-Old Children

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Language and Theory of Mind Brain Systems Were Already Distinct in 3- to 9-Year-Old Children

TL;DR: A 2026 Communications Biology fMRI study found that language and theory of mind, the ability to infer other people’s mental states, were already neurally distinct in children aged 3-9 rather than slowly separating during development. Key Findings Children show distinct neural specificity for language and theory of mind in superior temporal lobe — just …

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Intestinal Epithelial Serotonin Reduced Anxiety and Depression-Like Behavior via Vagus in Mice; In Utero SSRI Linked to Infant Constipation

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Intestinal Epithelial Serotonin Reduced Anxiety and Depression-Like Behavior via Vagus in Mice; In Utero SSRI Linked to Infant Constipation

TL;DR: A 2024 Gastroenterology study found that intestinal epithelial serotonin reduced anxiety- and depression-like behavior in mice through vagal signaling, while prenatal SSRI exposure in a human cohort predicted infant functional constipation independent of maternal depression. Key Findings Gut-only serotonin reuptake transporter ablation reduced anxiety and depression-like behavior: Targeting SERT only in the intestinal epithelium …

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