TL;DR: A reviewed preprint in eLife found that adult vestibular hair-cell kinocilia carry both primary-cilia and motile-cilia features, including motile-cilia gene signatures and spontaneous motion in bullfrog and mouse balance organs. Key Findings 1,522 mouse hair cells: The single-cell RNA-seq dataset included cochlear inner and outer hair cells plus vestibular type I and type II …
TL;DR: A 2026 preprint in medRxiv reported that a urine beta-amyloid protein test kit separated mild cognitive impairment or Alzheimer’s disease from healthy controls in a multicenter Chinese sample, while a 51,187-person community screen showed age-related positive rates. Key Findings 898-person validation sample: The multicenter case-control arm included 266 healthy controls, 167 people with mild …
TL;DR: A 2026 computational study in PLOS One used GEO Alzheimer’s datasets, 130 machine-learning models, and molecular simulations to identify eight candidate genes that may sit in a trichostatin A-related Alzheimer’s disease network. Key Findings 949 predicted TSA targets: The analysis started with predicted human protein targets for trichostatin A, a histone deacetylase inhibitor. Five …
TL;DR: A 2026 study in Biological Psychiatry: Global Open Science linked serious physical injury to recurrent major depression and found that injury-related DNA methylation patterns differed by depression status, with oxytocin, GABA, and synaptic-plasticity pathways standing out. Key Findings Large cohort anchor: researchers analyzed 4,308 Generation Scotland participants with or without a reported fracture from …
TL;DR: A 2026 study in Brain, Behavior, & Immunity – Health reported that Theiler’s murine encephalomyelitis virus (TMEV), a mouse neurotropic virus, infected substantia nigra dopamine neurons and produced Parkinson’s-like motor deficits in mice. Key Findings 13 TMEV mice vs 14 controls: The main behavioral experiment compared unilateral TMEV injection into the substantia nigra with …
TL;DR: A 2026 preprint in medRxiv reported that one session of left central thalamus focused ultrasound increased behavioral responsiveness scores in 16 adults with chronic disorders of consciousness, with no severe adverse events reported. Key Findings 16 chronic DOC patients: Adults had chronic disorders of consciousness after severe brain injury, with an average time since …
TL;DR: A 2026 review in CNS Drugs argues that seletracetam, an unapproved SV2A-targeting antiseizure drug, may deserve renewed development as a low-volume intranasal non-benzodiazepine rescue treatment for acute repetitive seizures. Key Findings SV2A racetam: Seletracetam is a second-generation racetam related to levetiracetam and brivaracetam. Phase IIa history: Oral seletracetam reached early clinical trials but was …
TL;DR: A 2026 medRxiv preprint introduced a 68-component NeuroMark template for single photon emission computed tomography (SPECT), a brain blood-flow imaging method, and found schizophrenia-related differences in cerebellar, subcortical, higher-cognition, visual, and triple-network perfusion patterns. Key Findings Template build: Researchers used blind independent component analysis on two large SPECT datasets of 5,001 and 5,000 scans …
TL;DR: A 2026 systematic review and meta-analysis in International Journal of Molecular Sciences found no significant global gut-microbiome alpha-diversity difference in schizophrenia, but reported recurring community-composition and taxonomic shifts. Key Findings 48 studies: The review included 48 human observational studies published between 2017 and 2025. 14 meta-analyzed studies: Only 14 studies provided enough data for …
TL;DR: A 2026 preprint on medRxiv used multisite MRI data from 3,958 people with schizophrenia and 5,489 controls to map cortical network disruptions and identify two robust brain-structure subtypes. Key Findings 9,447 MRI participants: The analysis included 3,958 individuals with schizophrenia and 5,489 neurotypical controls from 40 centers. Gradient alterations: Schizophrenia was linked with widespread …
