Cognitive Decline

Omega-3 Fatty Acids & Souvenaid® May Slow Cognitive Decline in Alzheimer’s Disease (2024 Review)

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Omega-3 supplements and Souvenaid® show potential in slowing cognitive decline in Alzheimer’s patients, though the evidence remains inconclusive. Highlights: Cognitive Decline Reduction: The CDR scale showed a significant reduction in cognitive decline progression with Omega-3 supplementation (SMD = −0.4127, 95% CI: [−0.5926; −0.2327]). Mixed Cognitive Outcomes: 58% of studies reported positive cognitive effects from Omega-3 …

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ACOT7 Biomarker May Help in Early Diagnosis of Alzheimers Disease (2024 Study)

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ACOT7 shows promise as a non-invasive serum biomarker for Alzheimer’s disease (AD) with high diagnostic accuracy. Highlights: Increased Expression: ACOT7 levels were significantly elevated in AD patients and animal models compared to controls. Correlation with Cognitive Decline: A strong negative correlation was observed between serum ACOT7 levels and MMSE scores (r = -0.85; p < …

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Blood Urea Nitrogen (BUN) & Creatinine Ratio vs. Cognition & Depression (2024 Study)

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Elevated blood urea nitrogen and creatinine ratio (BUNCr) is associated with decreased cognitive function and increased depressive symptoms, with depressive symptoms mediating part of the relationship between BUNCr and cognitive decline. Highlights: BUNCr has a negative association with cognitive function, with higher BUNCr levels linked to lower cognitive performance. BUNCr is positively associated with depressive …

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High Stress in Midlife Linked to Dementia in Women (2024 Study)

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Women experiencing midlife stress-related exhaustion have a higher risk of developing dementia at a younger age and exhibit long-term cognitive impairments. Highlights: Higher Dementia Risk: Women with midlife stress-related exhaustion had a nearly threefold increased risk of developing dementia before age 75. Earlier Onset: The average age of dementia onset was younger for women with …

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Hypertension Linked to Impaired Cognition & Gait in Older Adults (2024 Study)

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Hypertension in older adults leads to poorer cognitive and walking performance due to the need for more brain resources to manage dual tasks. Highlights: Older adults with hypertension show higher brain activation in motor and sensory areas when performing dual cognitive-walking tasks compared to healthy peers. Hypertensive individuals have worse cognitive performance on single cognitive …

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Peptide PHDP5 May Reverse Cognitive Impairment in Alzheimers Disease (2024 Research)

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TLDR: Researchers demonstrated that intranasal administration of the peptide FITC-PHDP5-CPP reverses early cognitive impairment in Alzheimer’s disease (AD) model mice, showing potential as a treatment for AD-associated cognitive decline. Highlights: PHDP5, derived from the pleckstrin homology domain of dynamin 1, inhibits the interaction between dynamin and microtubules, rescuing synaptic dysfunction caused by tau accumulation. The …

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Marijuana & Early-Onset Dementia (Age 34): Case Report Involving Cannabis Abuse

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A recent case report describes a 34-year old man who developed a rare form of early onset dementia after two years of heavy marijuana use. While concerning, experts say more research is needed to understand the potential risks of cannabis on the developing brain. Key Facts: The man developed frontotemporal dementia, a disorder causing personality …

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Dopamine in Parkinsons Disease: Insights & Future Therapies

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Parkinson’s disease (PD) is a neurodegenerative disorder characterized by the loss of dopamine-producing neurons. Dopamine plays an important role in PD development. Here are some key facts: Dopamine is a chemical messenger in the brain involved in movement, motivation, and mood. Loss of dopamine-producing neurons causes the motor symptoms of PD like tremors, rigidity, and …

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Link Between Insomnia, Short Sleep Duration, Dementia Risk: Insights from a 19-Year Swedish Study

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Trouble sleeping may raise your risk of dementia later in life, according to a new 19-year study of over 22,000 middle-aged and older adults in Sweden. Both insomnia symptoms and shorter sleep were linked to higher chances of developing dementia down the road. Key facts: Adults reporting insomnia symptoms had an 18% higher risk of …

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New Alzheimer’s Drug Aducanumab Promising But “ARIA” Side Effects Require Careful Monitoring

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A new drug recently approved for Alzheimer’s disease aims to treat the underlying cause of the condition by removing amyloid plaques in the brain. Though promising, the drug called aducanumab also comes with potential side effects that require careful monitoring. Key facts: Aducanumab is the first drug that targets and removes amyloid plaques, sticky buildups …

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