ACOT7 shows promise as a non-invasive serum biomarker for Alzheimer’s disease (AD) with high diagnostic accuracy. Highlights: Increased Expression: ACOT7 levels were significantly elevated in AD patients and animal models compared to controls. Correlation with Cognitive Decline: A strong negative correlation was observed between serum ACOT7 levels and MMSE scores (r = -0.85; p < …
CYP2C19 poor metabolizers showed a nominally higher antidepressant remission rate compared to normal metabolizers, but overall genetic variations in CYP2C19 and CYP2D6 were not significantly associated with antidepressant response. Highlights: Higher Remission Rate: CYP2C19 poor metabolizers had a nominally higher remission rate (OR = 1.46) compared to normal metabolizers, but this did not hold after …
Elevated methylmalonic acid (MMA) levels are associated with depressive symptoms and increased mortality risk, but depressive symptoms do not mediate the relationship between MMA and mortality. Highlights: Each standard deviation increase in MMA is associated with a small but significant increase in depressive symptoms. The association between MMA and depressive symptoms is more pronounced in …
Transcranial direct current stimulation (tDCS) targeting the left dorsolateral prefrontal cortex (DLPFC) at 2-mA intensity effectively alleviates depressive symptoms and shows promise in reducing anxiety symptoms across various clinical conditions. Highlights: tDCS targeting the left DLPFC significantly reduces depressive symptoms, highlighting it as a transdiagnostic neural mechanism across diverse clinical conditions. The meta-analysis showed that …
Elevated blood urea nitrogen and creatinine ratio (BUNCr) is associated with decreased cognitive function and increased depressive symptoms, with depressive symptoms mediating part of the relationship between BUNCr and cognitive decline. Highlights: BUNCr has a negative association with cognitive function, with higher BUNCr levels linked to lower cognitive performance. BUNCr is positively associated with depressive …
Optical coherence tomography (OCT) reveals significant retinal nerve fiber layer (RNFL) thinning in Parkinson’s disease (PD) patients, correlating with disease severity and suggesting OCT as a potential biomarker for PD diagnosis and monitoring. Highlights: RNFL Thinning: Parkinson’s disease patients exhibit significant thinning of the retinal nerve fiber layer (RNFL) compared to non-PD individuals (p = …
Women experiencing midlife stress-related exhaustion have a higher risk of developing dementia at a younger age and exhibit long-term cognitive impairments. Highlights: Higher Dementia Risk: Women with midlife stress-related exhaustion had a nearly threefold increased risk of developing dementia before age 75. Earlier Onset: The average age of dementia onset was younger for women with …
Higher ethylene oxide (EtO) exposure is significantly associated with an increased risk of stroke in U.S. adults, particularly those under 50 years old. Highlights: Higher levels of EtO are linked to increased stroke rates, with individuals in the top 25% of exposure showing a stroke prevalence 1.6 times higher than those in the bottom 25%. …
Occlusion dysfunction (OD) is causally linked to an increased risk of Alzheimer’s disease (AD), while dentures restoration can mitigate this risk. Highlights: Periodontal disease (PD) and Alzheimer’s do not have a direct causal relationship (P = 0.395). Loose teeth significantly increase the risk of AD progression (P = 0.017, OR = 187.3567). Dentures restoration is …
Necrostatin-1, an inhibitor of necroptosis, exhibits significant neuroprotective effects and potential therapeutic applications in various neurological disorders by modulating cell death pathways, inflammation, and reactive oxygen species. Highlights: Mechanism of Action: Necrostatin-1 specifically inhibits receptor-interacting protein 1 (RIP1), preventing necroptosis and other cell death pathways, including apoptosis and ferroptosis. Neuroprotective Role: It shows promise in …
