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TL;DR: A 2026 medRxiv preprint found that hospital stakeholders saw a need for CARES, a Comprehensive Addiction Risk Evaluation System combining genetic and behavioral/environmental risk information, but warned that provider burden, substance-use stigma, and w…
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TL;DR: A 2026 medRxiv preprint reported that ventral capsule deep brain stimulation (DBS), an implanted brain-stimulation treatment, reduced severe treatment-resistant obsessive-compulsive disorder (OCD) symptoms by 22 Yale-Brown Obsessive-Compulsive Scale (Y-…
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TL;DR: A 2026 medRxiv preprint found that serum hydrogen sulfide (H2S) levels, a blood measure tied to brain signaling and inflammation biology, were about 7.7-fold lower in drug-naive major depressive disorder patients than in matched controls. Key Findings 1…
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TL;DR: A 2025 survey study in Archives of Sexual Behavior linked violent pornography use to higher self-reported sexual aggression risk among university students, especially when pornography was perceived as realistic and peer rape myth acceptance was high. Ke…
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TL;DR: A 2026 mouse preprint in bioRxiv found that psilocybin reduced firing in somatostatin (SST) interneurons, inhibitory cortical cells that gate dendritic input, while increasing parvalbumin (PV) interneuron firing in the medial frontal cortex. Key Finding…
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TL;DR: A 2026 systematic review and meta-analysis in Neuropsychopharmacology found that dopamine D2-like receptor activation suppressed glucose-stimulated insulin secretion (GSIS), insulin release after high glucose, in animal pancreatic cells, suggesting one…
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TL;DR: A 2025 scoping review in European Psychiatry screened 292 randomized trials of adults diagnosed with attention-deficit/hyperactivity disorder (ADHD) and reported that 49.7% did not assess general psychopathology and only 35% had the ADHD diagnosis alloc…
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TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the pr…
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TL;DR: A 2026 medRxiv preprint linked post-stroke depressive symptoms to stroke damage in serotonin-transporter and acetylcholine-transporter weighted brain networks, suggesting depression risk after stroke may depend partly on which neurochemical circuits a l…
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TL;DR: A 2026 cross-sectional study in PLOS One found that euthymic bipolar disorder patients with early systematic antidepressant treatment had higher negative affect and higher attentional, non-planning, and total impulsivity scores than matched patients wit…
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