Neuropsychiatric Disorders

Methylphenidate Reduced Dishonesty in Healthy Adults Compared to Placebo in Double-Blind Trial

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Methylphenidate Reduced Dishonesty in Healthy Adults Compared to Placebo in Double-Blind Trial

TL;DR: A 2026 double-blind trial in Psychopharmacology found that methylphenidate reduced cheating in healthy adults compared with placebo, contrary to survey respondents’ expectations about smart drugs. Key Findings Methylphenidate reduced dishonesty vs placebo: A double-blind placebo-controlled experiment in healthy adults showed methylphenidate (Ritalin) reduced cheating behavior compared to placebo — the opposite direction from what …

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Stress Internalization Predicted Memory Decline in 1,528 Older Chinese Americans Across Three Waves

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Stress Internalization Predicted Memory Decline in 1,528 Older Chinese Americans Across Three Waves

TL;DR: A 2025 study in The Journal of Prevention of Alzheimer’s Disease found that stress internalization, not acculturation or activity engagement, predicted memory decline across three waves in 1,528 older Chinese Americans. Key Findings Stress internalization predicted longitudinal memory decline: A latent factor combining greater perceived stress, greater hopelessness, and lower conscientiousness was the single …

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Maternal Health Autism Links Were Partly Genetic in Danish Families

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Maternal Health Autism Links Were Partly Genetic in Danish Families

TL;DR: A 2026 preprint registry-family study in medRxiv found that some maternal diagnosis-autism associations fit shared direct genetic effects, while other diagnoses showed stronger parallel-cousin associations, suggesting indirect genetic effects through the prenatal environment. Key Findings Study type: a three-generation Danish register study comparing full maternal parallel and cross cousin pairs. People studied: 1,131,899 children …

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Inaudible Infrasound Increased Stress Hormones and Negative Mood in Controlled Trial

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Inaudible Infrasound Increased Stress Hormones and Negative Mood in Controlled Trial

TL;DR: A 2026 Frontiers in Behavioral Neuroscience study reported that inaudible infrasound shifted mood toward unease and raised stress-hormone markers under controlled conditions, offering a physiological explanation for some room-specific fear sensations without supporting supernatural claims. Key Findings Inaudible infrasound shifted mood: Controlled exposure produced measurable mood changes — toward unease, anxiety, and a felt …

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Loneliness-Isolation Mismatch Predicted Cognition Through Chronic Disease

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Loneliness-Isolation Mismatch Predicted Cognition Through Chronic Disease

TL;DR: A 2026 MIDUS mediation study in Brain, Behavior, & Immunity – Health found that social asymmetry was associated with greater chronic disease burden, while chronic disease burden mediated links between social asymmetry and episodic memory and executive function, while allostatic load did not. Key Findings Study type: a structural equation modeling study of social …

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Lateral Septal PACAP Signaling Regulated Stress and Anxiety Responses

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Lateral Septal PACAP Signaling Regulated Stress and Anxiety Responses

TL;DR: A 2026 rat study in Neuropsychopharmacology found that PACAP/PAC1 signaling in the lateral septum changed forced-swim coping, ACTH stress-hormone release, open-arm exploration, and grooming behavior. Key Findings Stress changed PACAP signals by brain region: Acute swim stress increased PACAP mRNA in the lateral septum, BNST, and basolateral amygdala, while chronic variable mild stress reduced …

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Late-Window Stroke IVT Did Not Improve Thrombectomy Outcomes

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Late-Window Stroke IVT Did Not Improve Thrombectomy Outcomes

TL;DR: A 2026 medRxiv preprint found that giving intravenous thrombolysis (IVT), a clot-dissolving drug treatment, before endovascular thrombectomy (EVT), a catheter procedure to remove a large brain clot, did not significantly improve 3-month recovery or increase bleeding risk in selected stroke patients treated 6 to 24 hours after symptoms began. Key Findings Registry cohort: The …

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Parental Severe Mental Illness Linked to Offspring Cognitive Performance

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Parental Severe Mental Illness Linked to Offspring Cognitive Performance

TL;DR: A 2026 Psychological Medicine meta-analysis of 109 studies linked parental severe mental illness, especially schizophrenia and bipolar disorder, to lower cognitive performance in offspring across IQ, language, memory, executive function, and general cognition. Key Findings Scale: The review included 109 studies and 1,586,339 participants. Schizophrenia: Offspring of parents with schizophrenia had lower scores across …

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Oral Acetate Case Series Found Metabolic Improvements in Psychotropic Weight Gain

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Oral Acetate Case Series Found Metabolic Improvements in Psychotropic Weight Gain

TL;DR: A 2026 case-series study in Translational Psychiatry tested delayed-release oral acetate from apple cider vinegar capsules in 11 young adults taking psychotropic medications and found high adherence, no product-related adverse events, microbiome shifts, and metabolic improvement in 6 participants, but the uncontrolled design means the findings need placebo-controlled testing. Key Findings 11 completers: The …

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Consonant Chord Progressions With Face Gaze Increased Social Brain Activity

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Consonant Chord Progressions With Face Gaze Increased Social Brain Activity

TL;DR: A 2026 study in The Journal of Neuroscience found that listening to consonant chord progressions while looking at a live partner increased functional near-infrared spectroscopy (fNIRS), a scalp blood-flow measure, in social brain systems. Key Findings Dyadic design: The study tested 20 participant pairs while both partners were recorded at the same time. Two …

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