Neuroscience

Cognitive Reserve in First-Episode Psychosis Linked to Genetics and Onset

by
Cognitive Reserve in First-Episode Psychosis Linked to Genetics and Onset

TL;DR: A 2026 study in Psychological Medicine found that cognitive reserve in non-affective first-episode psychosis was higher with greater genetic predisposition to educational attainment and lower with earlier psychosis onset or family history of psychosis. Key Findings 174 first-episode patients: Researchers analyzed people with non-affective first-episode psychosis, with a mean age of 25.5 years. Educational-attainment …

Read more

Chronic Mild Stress Increased Dopamine D1 Binding Across Mouse Striatum

by
Chronic Mild Stress Increased Dopamine D1 Binding Across Mouse Striatum

TL;DR: A 2026 mouse study in Neurochemical Research found that 28 days of unpredictable chronic mild stress increased dopamine D1 receptor binding across the striatum and raised dopamine D2 receptor binding only in selected regions, regardless of fatty acid-binding protein 7 gene deletion. Key Findings Adult male mice were exposed to 28 days of unpredictable …

Read more

400 mg Powdered CBD Formulation Absorbed Faster Than Epidyolex

by
400 mg Powdered CBD Formulation Absorbed Faster Than Epidyolex

TL;DR: A 2026 Phase I study in CNS Drugs found that a 400 mg powdered cannabidiol (CBD) formulation reached peak blood levels faster than oil-based Epidyolex, especially after a high-fat meal, while both products were generally well tolerated in healthy adults. Key Findings Four-way crossover trial: Researchers gave 32 healthy adults single 400 mg doses …

Read more

CB1 Receptor Autophagy Did Not Explain p62 Mouse Obesity Phenotype

by
CB1 Receptor Autophagy Did Not Explain p62 Mouse Obesity Phenotype

TL;DR: A 2026 study in Biochemistry and Biophysics Reports found that cannabinoid receptor 1 (CB1R) undergoes autophagy-linked degradation in mouse cortical neurons, but p62 deficiency did not make CB1R the main driver of obesity and low activity in p62 knockout mice. Key Findings CB1R accumulated up to 10-fold: Blocking autophagic flux with Bafilomycin A1 in …

Read more

Brain Connectivity Predicted Learning and Extinction Differences

by
Brain Connectivity Predicted Learning and Extinction Differences

TL;DR: A 2026 study in Nature Communications found that different brain-connectivity measures predicted different parts of associative learning: functional connectivity predicted acquisition, structural connectivity predicted extinction learning, and effective connectivity was most informative for renewal. Key Findings 509 resting-state fMRI scans: Researchers analyzed resting-state functional MRI data from 509 participants across six learning studies. 463 …

Read more

Birth DNA Methylation and DMN-Limbic Growth Predicted Age-13 Anxiety in Boys

by
Birth DNA Methylation and DMN-Limbic Growth Predicted Age-13 Anxiety in Boys

TL;DR: A 2026 Research Square preprint linked DNA methylation (DNAm), an epigenetic mark measured in cord blood at birth, with default mode network-limbic brain development and age-13 anxiety symptoms in boys. Key Findings Birth-to-teen pathway tested: Researchers analyzed 97 children from the GUSTO birth cohort who had cord-blood DNAm, repeated resting-state functional MRI (fMRI) scans, …

Read more

Autistic Children Rated Navigation Lower Despite Similar Task Performance

by
Autistic Children Rated Navigation Lower Despite Similar Task Performance

TL;DR: A 2026 preprint in medRxiv found that 26 autistic children and 25 typically developing peers performed similarly on iPad-based navigation tasks, but the autistic group rated its own sense of direction lower. Key Findings Objective navigation performance did not differ between autistic and typically developing children across path integration, egocentric pointing, mapping, or perspective …

Read more

Aripiprazole Linked to Oculogyric Crisis in Tourette Case Reports

by
Aripiprazole Linked to Oculogyric Crisis in Tourette Case Reports

TL;DR: A 2026 case study in Neurological Sciences described 2 Tourette syndrome patients who developed oculogyric crisis, a sustained upward eye-rolling dystonia, after aripiprazole was increased to 20-30 mg/day, with both cases resolving after dose reduction. Key Findings 2 Tourette cases: The report described 2 female patients, ages 16 and 22, treated with aripiprazole for …

Read more

Adult ADHD Linked to Lower SIRT-1, Nrf-2, and HO-1 Biomarkers

by
Adult ADHD Linked to Lower SIRT-1, Nrf-2, and HO-1 Biomarkers

TL;DR: A 2026 cross-sectional study in Metabolic Brain Disease linked adult attention-deficit/hyperactivity disorder (ADHD) with lower serum SIRT-1, Nrf-2, and HO-1, three redox-regulation markers tied to antioxidant defense. Key Findings 120 adults studied: The analysis compared 60 adults with ADHD against 60 age- and sex-matched healthy controls. SIRT-1 was lower: Mean serum SIRT-1 was 9.36 …

Read more

AD8 Dementia Screening Items Tracked Psychosocial Risk in Chinese Older Adults

by
AD8 Dementia Screening Items Tracked Psychosocial Risk in Chinese Older Adults

TL;DR: A 2026 medRxiv preprint found that specific AD8 dementia-screening items, especially judgment, repetition, finances, tool use, and daily memory problems, tracked functional and psychosocial vulnerability in 144 Chinese-speaking older adults. Key Findings Small community sample: The cross-sectional study included 144 Chinese-speaking adults with a mean age of 73.1 years. Three AD8 domains: Exploratory factor …

Read more

+ Load more