BrainASAP

Leigh Syndrome Organoid Drug Screen Identified Talarozole and Sertaconazole

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Leigh Syndrome Organoid Drug Screen Identified Talarozole and Sertaconazole

TL;DR: A 2026 study in Nature Communications used deep learning, yeast screening, and human brain organoids to identify talarozole and sertaconazole as preclinical candidates that rescued several SURF1-related Leigh syndrome cell and organoid phenotypes. Key Findings 2,250-drug yeast screen: Researchers screened a repurposable-drug library in a yeast model carrying a SURF1-homologue defect and selected top …

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Chicory and Green Tea Sleep Supplement Did Not Beat Placebo in Insomnia Pilot

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Chicory and Green Tea Sleep Supplement Did Not Beat Placebo in Insomnia Pilot

TL;DR: A 2026 pilot trial in PLOS One found that a 7-day chicory-and-green-tea herbal supplement did not improve sleep, quality of life, or objective sleep architecture more than placebo in adults with insomnia. Key Findings Small crossover pilot: The crossover pilot enrolled 10 adults aged 50 years or older with insomnia; 9 were women and …

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MSC Membrane Nanoparticles Improved Doxorubicin-Curcumin Glioblastoma Delivery

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MSC Membrane Nanoparticles Improved Doxorubicin-Curcumin Glioblastoma Delivery

TL;DR: A 2026 preclinical study in the International Journal of Nanomedicine developed human umbilical cord mesenchymal stem cell membrane-coated PLGA nanoparticles to co-deliver doxorubicin and curcumin to glioblastoma models, improving tumor-cell uptake and mouse tumor suppression without proving human efficacy. Key Findings MSC membrane coating: Researchers coated PLGA nanoparticles with human umbilical cord mesenchymal stem …

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Dentate Nucleus Deep Brain Stimulation Improved Cerebellar Ataxia Symptoms Across 27 Patients in Systematic Review

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Dentate Nucleus Deep Brain Stimulation Improved Cerebellar Ataxia Symptoms Across 27 Patients in Systematic Review

TL;DR: A 2026 systematic review in The Cerebellum found that deep brain stimulation (DBS) produced modest symptom improvement in selected cerebellar ataxia patients, with dentate nucleus stimulation most common in humans and interposed nucleus stimulation emerging from animal studies. Key Findings Dentate nucleus is the dominant human DBS target: Across 15 clinical studies (27 patients), …

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Amygdala-ACC Connectivity Was Reduced in Anxiety Disorders Meta-Analysis

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Amygdala-ACC Connectivity Was Reduced in Anxiety Disorders Meta-Analysis

TL;DR: A 2026 meta-analysis in Psychological Medicine found that reduced resting-state connectivity between the amygdala and anterior cingulate cortex was the most robust brain-network difference in anxiety disorders. Key Findings 15 datasets: The meta-analysis pooled 14 studies with 15 independent datasets of amygdala-based resting-state functional MRI. 783 total participants: Included samples covered 378 people with …

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AI Identified CgA-KO/PS19 Mouse Model of Asymptomatic Alzheimer’s Resilience

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AI Identified CgA-KO/PS19 Mouse Model of Asymptomatic Alzheimer’s Resilience

TL;DR: A 2026 study in Acta Neuropathologica Communications used Boolean-network AI analysis of Alzheimer’s RNA-seq data to identify a 40-gene disease signature and validate CgA-KO/PS19 mice as a model of asymptomatic Alzheimer’s-like resilience. Key Findings 289-person training set: Boolean Network Explorer was trained on cortical RNA-seq data from 70 cognitively normal controls and 219 Alzheimer’s …

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Psychosis in Lupus Linked to Immune Disease Activity in Review

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Psychosis in Lupus Linked to Immune Disease Activity in Review

TL;DR: A 2026 systematic review and meta-analysis in Lupus found that psychosis affected about 4.5% of adults with systemic lupus erythematosus (SLE), was more common in neuropsychiatric SLE, and tracked most strongly with active immune disease markers rather than serving as a stand-alone psychiatric label. Key Findings Sixty-five studies were included: The review covered 31,495 …

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Head Impact MEG Changes Mapped to Neurochemical Brain Systems

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Head Impact MEG Changes Mapped to Neurochemical Brain Systems

TL;DR: A 2026 preprint in medRxiv found that head-impact-related magnetoencephalography (MEG) changes in high-school football players were strongest in cortical regions matching specific neurotransmitter and gene-expression maps, especially norepinephrine, nicotinic acetylcholine, APOE, and BDNF-related patterns. Key Findings MEG tracked pre-to-post-season brain signaling across 278 timepoints from 91 male high-school football players. Concussion-related cortical slowing aligned …

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fMRI Noise Signal Tracked Nicotine Craving and Stimulant Effects

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fMRI Noise Signal Tracked Nicotine Craving and Stimulant Effects

TL;DR: A 2026 study in Biological Psychiatry: Global Open Science found that systemic low-frequency oscillation (sLFO), a slow whole-body physiology readout usually treated as functional MRI noise, tracked nicotine dependence, cue-induced craving, abstinence, and stimulant-related task performance across four fMRI cohorts. Key Findings The study analyzed four fMRI cohorts: Researchers examined a 64-person cigarette cue-reactivity …

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Early Psychosis Linked to Work and Education Disruption in SEEearly Cohort

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Early Psychosis Linked to Work and Education Disruption in SEEearly Cohort

TL;DR: A 2026 study in European Archives of Psychiatry and Clinical Neuroscience found that more than half of 184 young adults entering an early-psychosis supported employment and education trial were not in work, school, or training, even though nearly all had finished at least lower- or upper-secondary schooling. Key Findings The SEEearly cohort included 184 …

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