TLDR: LSD does not provide psychological resilience during stressful experiences such as job loss – and may increase psychological distress. Highlights: The study analyzed data from 5,067,553 unemployed individuals seeking jobs. LSD users who had used the drug more than a year before job loss were the focus to ensure accurate results. LSD use prior …
TLDR: GLP-1 agonists were found to significantly reduce the risk of dementia in older individuals with type 2 diabetes mellitus (T2DM) compared to DPP-4 inhibitors and sulfonylureas. Highlights: A sequential trial emulation was conducted using data from Swedish national registers from 2010 to 2020, involving 88,381 participants aged 65 or older with T2DM. The incidence …
TLDR: Researchers demonstrated that intranasal administration of the peptide FITC-PHDP5-CPP reverses early cognitive impairment in Alzheimer’s disease (AD) model mice, showing potential as a treatment for AD-associated cognitive decline. Highlights: PHDP5, derived from the pleckstrin homology domain of dynamin 1, inhibits the interaction between dynamin and microtubules, rescuing synaptic dysfunction caused by tau accumulation. The …
TLDR: A new method using sound to influence brain waves can help manage brain activity and affect how we fall asleep. Highlights: How It Works: This method, called Alpha Closed-Loop Auditory Stimulation (αCLAS), uses sound pulses timed precisely to brain waves to change brain activity. Phase Matters: The timing of the sound pulses is crucial; …
TLDR: This study provides evidence that high salt intake is causally associated with an increased risk of developing dementia, including Alzheimer’s disease (AD) and undefined dementia. Highlights: Causal Association: High salt intake is significantly associated with an increased risk of any dementia (OR = 1.73) and specifically Alzheimer’s disease (OR = 2.10). Cognitive Performance: Higher …
TLDR: High screen time exposure is significantly associated with an increased risk of myopia in children and adolescents, with computer use showing the strongest correlation, followed by television, while smartphone use shows no significant association. Highlights: Significant Link: The meta-analysis revealed a statistically significant correlation between high screen time exposure and increased risk of myopia …
TLDR: Occasional drinking may help reduce the risk of major depression, but frequent drinking worsens it. Highlights: Occasional alcohol consumption is linked to a lower risk of major depression. Frequent alcohol intake increases the risk of major depression. The risk increase from frequent drinking persists even when different types of alcohol are considered. The impact …
TLDR: Omega-3 supplementation shows potential for reducing anxiety symptoms, with the most significant improvement at a dose of 2 grams per day. Highlights: Dose-Dependent Effect: Each 1 gram per day of omega-3 supplementation led to a moderate decrease in anxiety symptoms, with the greatest improvement observed at 2 grams per day. Analysis: The meta-analysis included …
TLDR: This case study reports the highest recorded nonfatal clozapine overdose (10,000 mg) in an elderly patient, causing significant fluctuations in blood concentration levels following treatment. Highlights: A 71-year-old female ingested 10,000 mg of clozapine, significantly above typical overdose levels, leading to an initial blood concentration of 5200 μg/L. Despite initial treatment, blood clozapine levels …
TLDR: Quercetin-based alginate nanogels loaded with brain-derived neurotrophic factor (BDNF) can effectively cross the blood-brain barrier via intranasal delivery, providing a promising treatment for depressive disorders. Highlights: Nanogels: Quercetin nanogels protect BDNF from oxidative damage, exhibit rapid brain distribution, and significantly enhance bioavailability compared to oral administration. Efficacy: BDNF-Quercetin nanogels delivered via intranasal route show …
