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TL;DR: A 2026 study in Oncoscience reported that nitrosylcobalamin, a nitric-oxide-releasing vitamin B12 analog, crossed the blood-brain barrier in glioblastoma-bearing rats and accumulated in tumor tissue. Key Findings NO-Cbl defined: Nitrosylcobalamin is a c…
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TL;DR: A 2026 methodology paper in European Archives of Psychiatry and Clinical Neuroscience describes EMBER-MDD, a research-only multi-omic study designed to find treatment-resistance and esketamine-response biomarkers in about 420 adults with major depressiv…
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TL;DR: A 2026 review in Journal of Pain Research argues that postoperative pain care is moving away from opioid-centered prescribing toward multimodal, opioid-sparing protocols, with the strongest practical signal around NSAIDs paired with dexamethasone or reg…
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TL;DR: A 2026 review in International Journal of Molecular Medicine summarized how tanshinone IIA, a compound from Salvia miltiorrhiza, may protect cardiovascular and cerebrovascular tissue through anti-inflammatory, antioxidant, anti-apoptotic, and nanodelive…
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TL;DR: A 2026 study in Molecular Psychiatry found that radiofrequency capsulotomy and inferior thalamic peduncle deep brain stimulation were associated with the largest symptom improvements among surgical strategies for refractory obsessive-compulsive disorder…
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TL;DR: A 2026 study in Implementation Science Communications found that high-performing HEALing Communities Study coalitions used representative membership, shared goals, data support, and communications campaigns to strengthen opioid-use-disorder service impl…
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TL;DR: A 2026 Journal of Global Health analysis of Global Burden of Disease 2021 data estimated that 162.86 million people had substance use disorders in 2021, with age-standardized rates down since 1990 but major inequality across sex, age, region, and develo…
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TL;DR: A 2026 systematic review and meta-analysis in International Journal of Obesity found that glucagon-like peptide-1 receptor agonists, metabolic drugs that extend a satiety and glucose-control hormone pathway, reduced body weight mainly through fat loss w…
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TL;DR: A 2026 review in Drug Design, Development and Therapy argued that glucagon-like peptide-1 (GLP-1) receptor agonists, drugs that mimic a metabolic hormone involved in glucose control, have credible brain-protection mechanisms, but clinical evidence for n…
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TL;DR: A 2025 study in Journal of the American Chemical Society used photochemistry to turn amino-acid-linked tryptamines into azocinoindoles that activated serotonin 5-HT2A signaling while suppressing the mouse head-twitch response. Key Findings C4 indole rou…
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