TL;DR: A 2026 European Journal of Pediatrics study found that children with phenylketonuria, or PKU, had higher depression scores and lower quality of life than controls, with the worse pattern in children diagnosed later. Key Findings Children studied: The study included 76 children ages 8-15, split into early-diagnosed PKU, late-diagnosed PKU, and healthy control groups. …
TL;DR: A 2026 Neurological Sciences study followed 216 early Parkinson’s patients for 2 years after levodopa started and found that several non-motor symptom differences between men and women persisted or emerged despite adjustment for baseline scores and levodopa dose. Key Findings 216 early Parkinson’s patients completed 24-month follow-up after starting levodopa, including 139 men and …
TL;DR: A 2026 medRxiv preprint linked pre-surgery diffusion MRI markers in Parkinson’s disease to 6-month changes in impulsive-compulsive behaviour after subthalamic deep brain stimulation. Key Findings Small DBS cohort: Researchers followed 35 Parkinson’s disease patients from preoperative diffusion MRI to 6-month clinical follow-up after subthalamic deep brain stimulation. Behaviour score: Impulsive-compulsive behaviour was measured with …
TL;DR: A 2026 Nature Methods paper described a self-localized ultrafast pencil beam that made volumetric multiphoton imaging faster and more stable, including 1-minute 3D scans of transferrin uptake in a live human blood-brain barrier model. Key Findings Optics advance: A standard multimode fiber produced a stable, sidelobe-suppressed Bessel-like pencil beam near critical power. Microscopy fit: …
TL;DR: A 2026 study in Journal of Medical Case Reports described organophosphate-induced delayed neuropathy (OPIDN), a delayed nerve-injury syndrome, in a 44-year-old pesticide applicator after years of low-level exposure without a typical acute poisoning crisis. Key Findings 9-year exposure history: The patient had worked with chlorpyrifos, malathion, and diazinon for years, often 6-9 hours daily …
TL;DR: A 2026 mouse study in Communications Biology found that activating parvalbumin (PV) interneurons, inhibitory nerve cells in the orbitofrontal cortex, reduced default mode network connectivity and decreased normal social approach and sniffing behavior. Key Findings PV interneurons were targeted: Researchers used PV-Cre mice and a chemogenetic DREADD receptor to activate inhibitory PV interneurons in …
TL;DR: A 2026 retrospective ICU study in the International Journal of General Medicine found that 24-hour open visiting was associated with lower delirium incidence and lower anxiety/depression scores than 1-hour restricted visiting in chronic critically ill patients. Key Findings 264 ICU patients: The retrospective cohort included 132 restricted-visiting patients and 132 open-visiting patients. 24-hour access: …
TL;DR: A 2026 study in PLOS One found that Texas ICU COVID-19 hospitalizations coded for current nicotine dependence had lower crude and adjusted mortality than hospitalizations coded as never nicotine dependent, but the administrative-data design means the result should not be read as evidence that nicotine is protective. Key Findings Large ICU cohort: Researchers analyzed …
TL;DR: A 2026 randomized phase 2b trial in Journal of Clinical Psychopharmacology found that the PDE10A inhibitor MK-8189 did not improve Positive and Negative Syndrome Scale (PANSS) schizophrenia symptom scores more than placebo after 6 weeks, while risperidone separated from placebo in the same trial. Key Findings 458 treated participants: The acute phase included 132 …
TL;DR: A 2026 study in Neuropsychopharmacology used CRISPR gene editing in human microglia-like cells and found that several schizophrenia-linked genes changed phagocytosis, cell shape, and immune-transcription programs. Key Findings Schizophrenia-linked microglia genes were testable: The screen focused on 30 genes predicted from postmortem transcriptomic data and microglial biology to affect phagocytosis pathways. CYFIP1, MSR1, TREM2, …
