TL;DR: A 2026 study in Communications Medicine reported that artificial intelligence (AI) and multi-contrast MRI post-processing could reveal cortical lesions in multiple sclerosis trial scans that standard MRI review usually misses. Key Findings 80-person methods subset: Researchers analyzed 80 people with primary progressive multiple sclerosis from the phase 3 ORATORIO trial, then trained additional models …
TL;DR: A 2026 Nature Communications study found that chronic tumor necrosis factor alpha (TNF-alpha), an inflammatory cytokine, pushed human hippocampal progenitor cells toward type I interferon activity, lower neuroblast formation, and CXCR3-dependent T-cell recruitment. Key Findings 0.1-1 ng/ml TNF-alpha: The key experiments used chronic low-dose TNF-alpha exposures that the researchers considered biologically relevant for inflammatory …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Medical Internet Research found that care robots showed a low-certainty reduction in neuropsychiatric symptoms, but six other pooled outcome domains did not reach statistical significance. Key Findings 34 randomized trials: The review included 34 randomized controlled studies across 17 countries, with 2,476 participants. 20 meta-analyzed …
TL;DR: A 2026 narrative review in International Journal of General Medicine argued that apathy in Alzheimer’s disease is tied to damage across motivation circuits, including the anterior cingulate cortex, orbitofrontal cortex, striatum, locus coeruleus, and large-scale brain networks. Key Findings Apathy was framed as its own syndrome: The review separates reduced goal-directed behavior from depression, …
TL;DR: A 2026 review in International Journal of Molecular Medicine mapped how exercise and fluoxetine overlap in Alzheimer’s disease mechanisms such as mitochondrial quality control, oxidative stress, inflammation, and neuroplasticity, but clinical combination benefits remain unproven. Key Findings Review article, not trial: Wu and Li synthesized mechanistic evidence on exercise and fluoxetine in Alzheimer’s disease …
TL;DR: A 2026 preprint posted on medRxiv reported that larger choroid plexus volume on brain MRI was associated with greater disability in multiple sclerosis and with higher white-matter myo-inositol in progressive MS, but the work has not yet been peer reviewed. Key Findings 88-person imaging sample: Researchers studied 45 people with multiple sclerosis and 43 …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Alzheimer’s Disease found that choroid plexus volume, an MRI-visible structure involved in cerebrospinal-fluid regulation and immune signaling, was larger in Alzheimer’s disease than in healthy controls. Key Findings Sixteen studies: The review included 16 MRI-based studies covering 2,004 Alzheimer’s disease patients and 883 healthy controls. …
TL;DR: A 2026 study in European Journal of Nuclear Medicine and Molecular Imaging found that semiquantitative [123I]FP-CIT SPECT metrics, especially caudate-to-putamen and sensorimotor-to-limbic ratios, helped distinguish Parkinson’s disease from atypical parkinsonian syndromes, while a random forest classifier remained more useful as decision support than as a standalone diagnosis. Key Findings 706-patient cohort: The study included …
TL;DR: A 2026 real-world cohort study in The Journal of Prevention of Alzheimer’s Disease found that lecanemab-treated Alzheimer’s patients had lower Neuropsychiatric Inventory scores over follow-up, and 6-month symptom reductions were associated with regional amyloid-beta positron emission tomography (PET) clearance. Key Findings 144 treated patients: The cohort included people with Alzheimer’s-related mild cognitive impairment or …
TL;DR: A 2026 preprint on medRxiv found that blood tau markers and neurofilament light tracked different parts of amyotrophic lateral sclerosis (ALS), with tau markers linked more to current lower-motor-neuron and muscle-injury features while neurofilament light was the clearest marker of faster decline and shorter survival. Key Findings 119 ALS patients: Researchers measured plasma and …
