TL;DR: A 2026 medRxiv preprint found that one session of repetitive transcranial magnetic stimulation (rTMS) over the left dorsolateral prefrontal cortex (DLPFC) reduced cigarette craving in adults with tobacco use disorder, and the people who responded had heavier baseline smoking, craving, and withdrawal. Key Findings DLPFC craving test: The randomized crossover study included 60 adults …
TL;DR: A 2026 medRxiv preprint linked greater attention-deficit/hyperactivity disorder (ADHD) symptom scores in college students to reduced stop-signal functional MRI (fMRI) activation in cannabinoid receptor 1 (CB1R)-rich brain regions, and that reduced activation predicted heavier cannabis-use trajectories over 4 years. Key Findings ADHD-cannabis trajectory: Researchers analyzed cannabis-use trajectories in 466 first-year college students aged 18-19, …
TL;DR: A 2026 narrative review in Molecular Psychiatry argues that depression in Alzheimer’s disease and Parkinson’s disease follows disease-specific brain mechanisms, while standard antidepressant evidence remains weak in these neurodegenerative populations. Key Findings 42% in Alzheimer’s disease: The review cites depressive syndromes affecting about 42% of patients with Alzheimer’s disease and 35% of patients with …
TL;DR: A 2026 systematic review and meta-analysis in Molecular Psychiatry found that CB-1 receptor blockade and cannabidiol reduced alcohol intake in animal models, but human alcohol-use-disorder evidence remained inconsistent and too thin to support a treatment claim. Key Findings 63 studies reviewed: Researchers synthesized 44 preclinical studies and 19 clinical or human experimental studies of …
TL;DR: A 2026 meta-analysis in Journal of Medical Internet Research did not find a statistically significant reduction in Patient Health Questionnaire-9 (PHQ-9) depression scores with AI-driven chatbots, but emotionally responsive, structured, and frequent interactions were more consistently associated with user adherence. Key Findings 11 randomized trials: The review included 11 RCTs with 2220 participants for …
TL;DR: A 2026 study in International Clinical Psychopharmacology described a 40-year-old man whose dysphoria, anhedonia, amotivation, and fatigue appeared soon after olanzapine was changed to olanzapine-samidorphan and resolved after he returned to olanzapine alone. Key Findings One-patient case report: The report followed a 40-year-old man after first psychiatric hospitalization, so the evidence is a clinical …
TL;DR: A 2026 medRxiv retrospective cohort study found that depression often followed bipolar manic or mixed episodes quickly, with 25% of manic episodes and 22% of mixed episodes transitioning to depression within 1 month. Key Findings First-month risk window: Researchers analyzed 10,437 people, 42,314 mood episodes, and 90,727 person-years in a U.S. electronic health record …
TL;DR: A 2026 study in The British Journal of Psychiatry found that 4 weeks of twice-weekly subcutaneous racemic ketamine helped a minority of people with treatment-resistant depression, but response fell from 30% at treatment end to 17% 4 weeks later. Key Findings 130 trial participants entered the extension: All had treatment-resistant depression and a Montgomery-Asberg …
TL;DR: A 2026 study in Nature Communications reported that tubulin redirected Tau and alpha-synuclein condensates toward microtubule-building states, while tubulin loss pushed the same protein system toward toxic oligomers in cell models. Key Findings 36-hour shift: Tau and alpha-synuclein condensates formed stable high-molecular-weight oligomers and Tau:alpha-synuclein heterodimers after aging without tubulin. 10-micromolar tubulin: Adding tubulin …
TL;DR: A 2026 mouse and cell study in Nature found that developing neurons can generate DNA double-strand breaks while moving through narrow brain tissue during migration, then usually repair those breaks without cell death. Key Findings Developing neurons: The study tracked cerebellar granule neurons, Purkinje cells, and cortical neurons during normal brain development. Confined migration: …
