TL;DR: A 2026 pilot randomized trial in Nursing in Critical Care found that an 8-week home-based program combining exercise with computerized cognitive training was feasible in 36 ICU survivors and produced larger reductions in patient-reported post-intensive care syndrome severity than attention control, while exploratory cognitive and quality-of-life effect sizes generally favored the combined program over …
TL;DR: A 2026 review in International Journal of Nanomedicine argued that depression nanomedicine should move beyond blood-brain-barrier delivery alone and be judged by target engagement, neuroimmune-barrier-plasticity effects, safety, manufacturability, and patient stratification. Key Findings Mechanism-centered review: The paper organized depression nanomedicine around neuroinflammation, blood-brain-barrier dysfunction, oxidative stress, and impaired neuroplasticity. 3 strategy groups: The review …
TL;DR: A 2026 study in European Journal of Nuclear Medicine and Molecular Imaging found that semiquantitative [123I]FP-CIT SPECT metrics, especially caudate-to-putamen and sensorimotor-to-limbic ratios, helped distinguish Parkinson’s disease from atypical parkinsonian syndromes, while a random forest classifier remained more useful as decision support than as a standalone diagnosis. Key Findings 706-patient cohort: The study included …
TL;DR: A 2026 study in European Archives of Psychiatry and Clinical Neuroscience linked sustained quetiapine treatment with better high-working-memory cognitive performance in schizophrenia spectrum disorder, but the genetic tests did not support the proposed remyelination-moderation mechanism. Key Findings 166 matched pairs: The extended PsyCourse analysis included 166 quetiapine-treated schizophrenia-spectrum patients and 166 age- and sex-matched …
TL;DR: A 2026 real-world cohort study in The Journal of Prevention of Alzheimer’s Disease found that lecanemab-treated Alzheimer’s patients had lower Neuropsychiatric Inventory scores over follow-up, and 6-month symptom reductions were associated with regional amyloid-beta positron emission tomography (PET) clearance. Key Findings 144 treated patients: The cohort included people with Alzheimer’s-related mild cognitive impairment or …
TL;DR: A 2026 randomized trial in Physiotherapy Research International found that adding active 5 Hz repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex to dual-task stroke rehabilitation produced larger gains in Timed Up-and-Go performance, balance confidence, and cognitive screening than sham stimulation plus the same training. Key Findings Small randomized trial: The study …
TL;DR: A 2026 case study in Biomedical Reports described a 28-year-old woman with bipolar II disorder whose stable subclinical counting compulsion worsened and expanded into new obsessive-compulsive symptoms within 3 days of starting cariprazine, then returned near baseline within 7 days after the drug was stopped. Key Findings Single case report: The source described one …
TL;DR: A 2026 preprint on medRxiv found that blood tau markers and neurofilament light tracked different parts of amyotrophic lateral sclerosis (ALS), with tau markers linked more to current lower-motor-neuron and muscle-injury features while neurofilament light was the clearest marker of faster decline and shorter survival. Key Findings 119 ALS patients: Researchers measured plasma and …
TL;DR: A 2026 study in Translational Psychiatry found that ketamine changed EEG-derived high-order brain interactions in late-life treatment-resistant depression, and a 24-hour increase in alpha-band redundancy tracked greater depression improvement by Day 7. Key Findings 30 analyzed participants: The secondary analysis compared 18 ketamine-treated and 12 midazolam-treated late-life veterans with treatment-resistant depression at baseline. Single …
TL;DR: A 2026 study published in BMC Medicine used lesion network mapping to identify a somatic-symptom brain network centered on the right insula and putamen, then linked atrophy inside that network to somatic symptom severity across 399 psychiatric patients. Key Findings 21 lesions mapped: Lesions linked to somatic symptoms appeared in different brain locations but …
