Cognition

EMS Plus Low-Intensity Resistance Exercise Improved Inhibitory Control

by
EMS Plus Low-Intensity Resistance Exercise Improved Inhibitory Control

TL;DR: A 2026 crossover study in Clinical Physiology and Functional Imaging found that adding electrical muscle stimulation to low-intensity resistance exercise improved inhibitory control in young men, while stimulation alone showed a delayed 15-minute benefit. Key Findings 17 young men: Participants completed low-intensity resistance exercise, electrical muscle stimulation alone, and combined low-intensity exercise plus stimulation …

Read more

COMBAT-ICU Cognitive Training Reduced PICS Severity in Pilot Trial

by
COMBAT-ICU Cognitive Training Reduced PICS Severity in Pilot Trial

TL;DR: A 2026 pilot randomized trial in Nursing in Critical Care found that an 8-week home-based program combining exercise with computerized cognitive training was feasible in 36 ICU survivors and produced larger reductions in patient-reported post-intensive care syndrome severity than attention control, while exploratory cognitive and quality-of-life effect sizes generally favored the combined program over …

Read more

Quetiapine Linked to Better Working Memory in Schizophrenia

by
Quetiapine Linked to Better Working Memory in Schizophrenia

TL;DR: A 2026 study in European Archives of Psychiatry and Clinical Neuroscience linked sustained quetiapine treatment with better high-working-memory cognitive performance in schizophrenia spectrum disorder, but the genetic tests did not support the proposed remyelination-moderation mechanism. Key Findings 166 matched pairs: The extended PsyCourse analysis included 166 quetiapine-treated schizophrenia-spectrum patients and 166 age- and sex-matched …

Read more

DLPFC rTMS Improved Dual-Task Walking After Subacute Stroke

by
DLPFC rTMS Improved Dual-Task Walking After Subacute Stroke

TL;DR: A 2026 randomized trial in Physiotherapy Research International found that adding active 5 Hz repetitive transcranial magnetic stimulation (rTMS) over the dorsolateral prefrontal cortex to dual-task stroke rehabilitation produced larger gains in Timed Up-and-Go performance, balance confidence, and cognitive screening than sham stimulation plus the same training. Key Findings Small randomized trial: The study …

Read more

ADHD Symptoms Linked to Cannabis Use Through CNR1-Rich Inhibitory-Control Regions

by
ADHD Symptoms Linked to Cannabis Use Through CNR1-Rich Inhibitory-Control Regions

TL;DR: A 2026 medRxiv preprint linked greater attention-deficit/hyperactivity disorder (ADHD) symptom scores in college students to reduced stop-signal functional MRI (fMRI) activation in cannabinoid receptor 1 (CB1R)-rich brain regions, and that reduced activation predicted heavier cannabis-use trajectories over 4 years. Key Findings ADHD-cannabis trajectory: Researchers analyzed cannabis-use trajectories in 466 first-year college students aged 18-19, …

Read more

Home Exercise Trial Will Test Parkinson Cognition and Biomarkers

by
Home Exercise Trial Will Test Parkinson Cognition and Biomarkers

TL;DR: A 2026 protocol in JMIR Research Protocols describes EXCEL-PD, a randomized trial testing whether 26 weeks of virtually supervised home endurance and resistance exercise is feasible, safe, and biologically informative for people with Parkinson disease. Key Findings Home trial design: EXCEL-PD randomizes 31 planned participants with Parkinson disease to home-based exercise or waitlist usual …

Read more

PLTi Brainstem Neurons Controlled Spatial Attention in Mice

by
PLTi Brainstem Neurons Controlled Spatial Attention in Mice

TL;DR: A 2026 study in Nature Communications found that PLTi, an evolutionarily old group of inhibitory brainstem neurons, was required for mice to choose a goal-relevant visual target over lower-priority distractors. Key Findings PLTi defined: Parabigemino-lateral tegmental inhibitory complex neurons were mostly parvalbumin-positive GABAergic cells in the mouse brainstem. 95.01% overlap: Nearly all GABA-positive cells …

Read more

Basilar Artery Dolichoectasia Linked to Lacunar Stroke and cSVD

by
Basilar Artery Dolichoectasia Linked to Lacunar Stroke and cSVD

TL;DR: A 2026 prospective mild-stroke cohort study in Circulation linked basilar artery dolichoectasia and wider cranial arteries to lacunar stroke and cerebral small-vessel disease, while large-artery stenosis did not show the same association. Key Findings 229 mild-stroke patients: The Mild Stroke Study 3 cohort included lacunar and mild nonlacunar ischemic stroke patients followed with MRI …

Read more

Aged Gut Microbiome Impaired Mouse Memory via Vagal Gut-Brain Signaling

by
Aged Gut Microbiome Impaired Mouse Memory via Vagal Gut-Brain Signaling

TL;DR: A 2026 mouse study in Nature found that age-related gut microbiome changes impaired vagal gut-brain signaling and hippocampal memory encoding, while several interventions restored memory performance in aged or microbiome-aged mice. Key Findings Aged microbiome transfer impaired memory: Young mice exposed to aged gut microbes showed worse novel object recognition and Barnes maze performance …

Read more

Human Hippocampus Encoded Language During Propofol Anesthesia

by
Human Hippocampus Encoded Language During Propofol Anesthesia

TL;DR: A 2026 study in Nature recorded human hippocampal neurons during propofol anesthesia and found preserved oddball-tone discrimination, short-term plasticity, and language-related semantic coding during surgical loss of consciousness. Key Findings 7 surgical patients: Researchers recorded hippocampal activity with Neuropixels probes during general anesthesia in patients undergoing epilepsy surgery. 172 tone-responsive units: The tone task …

Read more

+ Load more