Medical

Transcriptomic Aging Was Accelerated in Major Depression and Linked to Right Insula Changes

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Transcriptomic Aging Was Accelerated in Major Depression and Linked to Right Insula Changes

TL;DR: A 2026 case-control study in Psychological Medicine linked major depressive disorder to faster blood-based transcriptomic aging and found that right-insula brain changes partly explained the depression association. Key Findings Transcriptomic aging was faster in depression: 141 people with major depressive disorder showed higher blood RNA-based aging acceleration than 134 healthy controls. The result strengthened …

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Parent-Implemented Autism Intervention Helped Chinese Preschoolers

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Parent-Implemented Autism Intervention Helped Chinese Preschoolers

TL;DR: A 2026 randomized trial in Molecular Autism found that a culturally adapted parent-implemented social communication program was linked to language, social-functioning, parent self-efficacy, and stress gains in Chinese-speaking autistic preschoolers, with no consistent advantage for therapist-led online groups over self-study across most outcomes. Key Findings Chinese preschoolers randomized: 112 autistic children aged 24-60 months …

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Refugee and Asylum Seeker Sleep Problems Were Common in Meta-Analysis

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Refugee and Asylum Seeker Sleep Problems Were Common in Meta-Analysis

TL;DR: A 2026 meta-analysis in PLOS One found clinically important sleep problems in refugee and asylum-seeking populations, with pooled sleep-adversity prevalence of 43.2% in adults and 36.4% in children and adolescents. Key Findings 66 studies reviewed: The systematic review and meta-analysis covered 42,956 refugees and asylum seekers. 43.2% adult prevalence: Pooled sleep-adversity prevalence in adults …

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Poor Sleep Tracked Faster Biological Aging, but Causation Was Mixed

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Poor Sleep Tracked Faster Biological Aging, but Causation Was Mixed

TL;DR: A 2026 preprint in medRxiv found that poor sleep tracked faster biological aging across more than 64,000 adults, but twin and genetic analyses left the causal claim mixed rather than settled. Key Findings 64,000+ adults: Researchers tested sleep and aging biomarkers across five independent datasets spanning young, middle, and late adulthood. Poorer sleep quality: …

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Esketamine Stellate Ganglion Block Reduced Postoperative Sleep Disturbance

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Esketamine Stellate Ganglion Block Reduced Postoperative Sleep Disturbance

TL;DR: A 2026 randomized trial in BMC Anesthesiology found that adding an esketamine-adjuvanted stellate ganglion block to intraoperative esketamine plus dexmedetomidine reduced early postoperative sleep disturbance after gynecological laparoscopic surgery. Key Findings Sleep disturbance fell on day 1: Postoperative sleep disturbance affected 62.9% of patients in the stellate ganglion block group versus 83.2% in controls. …

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Autistic Children With Speech Delay Showed Reversed Auditory Bias

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Autistic Children With Speech Delay Showed Reversed Auditory Bias

TL;DR: A 2026 study in Autism Research found that autistic children with early speech delay needed longer sound gaps to detect timing changes, but detected smaller pitch-frequency changes than typically developing peers. Key Findings 21 autistic children were compared with 23 typically developing children: The autism group had early language delay and early autistic manifestations, …

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Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

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Stroke Thrombectomy Technique Preference Did Not Predict First-Pass Reperfusion

TL;DR: A 2026 medRxiv preprint found that stroke thrombectomy operators often had a preferred device technique, but that preference did not reliably match the technique with the highest first-pass reperfusion rate. Key Findings Stroke thrombectomy cohort: The single-center analysis included 1,405 acute ischemic stroke patients treated with mechanical thrombectomy from 2019 through 2024. 75% had …

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Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

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Perinatal EEG Delta and Alpha Power Tracked Depression and Anxiety

TL;DR: Portable electroencephalography (EEG) recordings tracked perinatal anxiety most consistently in a preliminary medRxiv preprint, with delta power carrying the clearest longitudinal marker and alpha power appearing in visit-specific anxiety analyses. Key Findings First-trimester marker: Relative delta power before 16 gestational weeks was associated with third-trimester PHQ-9 depression and GAD-7 anxiety scores. Delta-anxiety link: Across …

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Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

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Syringe Service Buprenorphine Improved Access but Needed Withdrawal Support

TL;DR: A 2026 qualitative study in the Journal of Substance Use and Addiction Treatment found that syringe service programs helped people receive buprenorphine quickly, but participants said precipitated withdrawal and limited at-home initiation guidance made treatment harder to start and continue. Key Findings 12 exit interviews: Researchers interviewed people after a randomized trial of buprenorphine …

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Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

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Psilocybin Therapy for Anorexia Nervosa Improved EDE Symptoms in Pilot Study

TL;DR: A 2026 pilot study in The British Journal of Psychiatry tested psilocybin-assisted therapy in 21 adult females with anorexia nervosa and found lower Eating Disorder Examination (EDE) symptom scores through 6 months, with large individual variation and no placebo-controlled comparison. Key Findings Single-arm pilot study: Researchers enrolled 21 adult females with anorexia nervosa and …

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