Neuropsychiatric Disorders

25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

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25C-NBF, a Selective 5-HT2A Phenethylamine, Reduced Despair and Restored Sucrose Preference in Male Mice

TL;DR: A 2026 mouse and rat study in Molecular Psychiatry reported that 25C-NBF, a selective serotonin 2A receptor agonist from the 2C-X phenethylamine series, produced rapid antidepressant-like effects, increased dendritic spines and Bdnf expression in the prefrontal cortex, and showed no rewarding or reinforcing properties at the tested doses. Key Findings Despair behavior fell after …

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Targeted Memory Reactivation Changed Sleep Waves But Not Motor Retention in Parkinson’s

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Targeted Memory Reactivation Changed Sleep Waves But Not Motor Retention in Parkinson’s

TL;DR: A 2026 medRxiv preprint found that targeted memory reactivation (TMR), replaying learned sounds during non-REM sleep, changed spindle and slow-wave density during a nap but did not improve motor memory retention in Parkinson’s disease or healthy older adults. Key Findings Parkinson’s and healthy older adults were compared: The experiment included 20 people with Parkinson’s …

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Post-Stroke Depression Linked to Serotonin and Acetylcholine Network Damage

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Post-Stroke Depression Linked to Serotonin and Acetylcholine Network Damage

TL;DR: A 2026 medRxiv preprint linked post-stroke depressive symptoms to stroke damage in serotonin-transporter and acetylcholine-transporter weighted brain networks, suggesting depression risk after stroke may depend partly on which neurochemical circuits a lesion disrupts. Key Findings 435 stroke patients analyzed: Researchers combined two independent cohorts, Leipzig and Oxford, after exclusions for missing clinical variables and …

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NDST3 Suppression Restored Lysosomal Acidification in Alzheimer’s Models

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NDST3 Suppression Restored Lysosomal Acidification in Alzheimer’s Models

TL;DR: A 2026 study in Translational Neurodegeneration found that reducing NDST3, a microtubule deacetylase that affects lysosome acidity, restored lysosomal acidification and reduced amyloid-beta and tau pathology in Alzheimer’s cell and mouse models. Key Findings Lysosomal pH shifted back: APP695Swe-overexpressing HT22 cells had lysosomal pH near 5.6, while Ndst3 knockdown lowered it to less than …

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Early Antidepressant Treatment Linked to Higher Negative Affect and Impulsivity in Bipolar Euthymia

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Early Antidepressant Treatment Linked to Higher Negative Affect and Impulsivity in Bipolar Euthymia

TL;DR: A 2026 cross-sectional study in PLOS One found that euthymic bipolar disorder patients with early systematic antidepressant treatment had higher negative affect and higher attentional, non-planning, and total impulsivity scores than matched patients without that early antidepressant history. Key Findings 124 bipolar patients studied: Researchers compared 62 patients with early systematic antidepressant treatment and …

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Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

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Dexamethasone Disrupted Mouse Sleep Through Orexin Activation

TL;DR: A 2026 mouse study in Psychopharmacology found that repeated dexamethasone, a synthetic glucocorticoid steroid, disrupted light-phase sleep and increased orexin-neuron activity, a wake-promoting hypothalamic signal, during sleep-to-wake transitions. Key Findings 5-day steroid model: Male C57BL/6J mice received dexamethasone at 30 mg/kg for 5 days before 24-hour sleep recording. Light-phase sleep was disrupted: Dexamethasone increased …

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CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

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CBT-I Plus Medication Improved Chronic Insomnia More Than Medication Alone

TL;DR: A 2026 systematic review in Journal of Clinical Sleep Medicine found that cognitive behavioral therapy for insomnia (CBT-I), a structured behavioral sleep treatment, plus sleep medication improved chronic insomnia more than medication alone, but adding medication to CBT-I did not improve the critical insomnia outcomes. Key Findings 15 analyzable articles: Researchers screened 1,179 articles, …

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Olfactory MRI Radiomics Linked pTau217 to Alzheimer’s Cognition

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Olfactory MRI Radiomics Linked pTau217 to Alzheimer's Cognition

TL;DR: A 2026 article-in-press study in Alzheimer’s Research & Therapy found that olfactory-region MRI radiomics, a method that turns brain scans into quantitative texture and shape features, linked blood pTau217, a tau-related Alzheimer’s disease biomarker, with cognitive impairment across three cohorts. Key Findings Three Alzheimer’s cohorts were matched: Researchers matched 122 Alzheimer’s disease (AD) patients …

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Alzheimer’s AI Model Improved Disease Progression Prediction

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Alzheimer's AI Model Improved Disease Progression Prediction

TL;DR: A 2026 machine-learning study found that the final SNP-NF model in PLOS One reported mAUC 0.965, recall 0.929, and precision 0.929, while the study reported gains of about 3% in mAUC, 1% in precision, and 0.7% in recall versus their previous neural-process model. Key Findings SNP-NF performance was high: The final model reported mAUC …

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Social Media Abstinence Did Not Improve Mood or Life Satisfaction in 10-Study Meta-Analysis of 4,674 Adults

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Social Media Abstinence Did Not Improve Mood or Life Satisfaction in 10-Study Meta-Analysis of 4,674 Adults

TL;DR: A 2025 systematic review and meta-analysis in Scientific Reports pooled 10 social media abstinence experiments (N = 4,674 adults; abstinence 1–28 days) and found no significant effect on positive affect, negative affect, or life satisfaction. Key Findings Positive affect was unchanged: pooled Hedges’ g = 0.03 (95% CI [−0.11, 0.16], p = 0.69) across 9 studies and 14 …

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