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TL;DR: In a small Pakistan pilot, 23 of 25 adults given an Urdu version of a talk therapy for anxiety and depression finished all 14 weeks. The trial was too small to show the therapy works. Key Findings Signed up and stayed: 51 adults were randomly assigned t…
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TL;DR: Across 55 trials in low- and middle-income countries (5,041 adults), people who got therapy had much lower PTSD symptoms than people on a wait-list or other comparison. The evidence was very low certainty because many trials were weakly run. Key Finding…
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TL;DR: A therapy app did not reduce depression scores more than a look-alike education app in a trial of adults with past concussions. Insomnia scores improved more with the therapy app, but only 42 of 113 participants completed the main 12-week check-in. Key…
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TL;DR: A 2026 pooled analysis in CNS Drugs combined two six-week trials of adults whose depression hadn’t responded well enough to an antidepressant. Adding the antipsychotic lumateperone instead of a placebo raised the share of people with side effects from 4…
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TL;DR: A meta-analysis pooling 63 studies and 265,079 people found that cannabis users had about twice the odds of committing violence as non-users (2.05 times in the general population, 2.49 times among psychiatric patients). The gap shrank to 1.17 times in s…
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TL;DR: In a small German study of 24 refugee women with trauma symptoms, scores on three symptom questionnaires stayed flat during an 8-week wait, then dropped after 8 weekly dance movement therapy sessions. The group’s average PTSD checklist score slipped jus…
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TL;DR: A review of 17 randomized trials found that women who exercised had lower depression scores than women given usual care, both during pregnancy and after birth. The evidence is rated low to very low certainty, and the studies varied a lot. For anxiety du…
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TL;DR: A 2026 randomized trial in Journal of Medical Internet Research gave adults with elevated depression symptoms the same coach-led group skills program through either a VR headset or a flat screen. Depression scores fell slightly faster in the VR group ov…
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TL;DR: A 2026 mouse study in Nature Communications reported that 10 daily bouts of optogenetic dentate-gyrus stimulation produced weeks-long changes in chromatin, nuclear structure, behavior, and spatial coding, while Cyclin B deletion weakened several effects…
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TL;DR: A 2026 randomized study in Psychological Medicine reported that 7–10 days of prucalopride improved word-learning recall and working-memory response speed versus placebo in adults with remitted recurrent depression, but the 49-person analysis did not tes…
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