TL;DR: A 2026 mouse study in Journal of Extracellular Vesicles found that two intranasal doses of hiPSC-NSC-EVs reduced inflammatory pathway markers in the aged hippocampus and were associated with better memory performance. Key Findings Two-dose nasal treatment: Late middle-aged 18-month-old male and female C57BL/6J mice received two intranasal doses of hiPSC-NSC-EVs before assessment in old …
TL;DR: A 2026 preprint in medRxiv surveyed people with multiple system atrophy and found that neurogenic orthostatic hypotension was often underdiagnosed, rarely fully controlled, and strongly tied to daily function and caregiver burden. Key Findings 259 MSA respondents: The survey analyzed 259 people with self-reported multiple system atrophy, with mean age 64.38 years and 44% …
TL;DR: A 2026 preprint in medRxiv found that the ADAS-Cog-13 cognitive scale detected impairment in older adults with focal epilepsy, but a cutoff of 15 had only modest diagnostic accuracy against an epilepsy-specific neuropsychological standard. Key Findings 83 epilepsy patients: The study analyzed adults older than 55 with focal epilepsy from the Brain, Aging, and …
TL;DR: A 2026 Molecular Psychiatry study linked blood-derived microRNAs, short RNA regulators that help control gene expression, to left hippocampal volume and later brain atrophy in adults from the Rhineland Study. Key Findings Baseline MRI cohort: Researchers compared blood microRNA expression in 2,062 adults with baseline MRI measures of left and right hippocampal volume, hippocampal …
TL;DR: A 2025 study in Psychological Science found that depressive symptoms accelerated about 4 years before death in a multinational twin consortium, suggesting that late-life mood worsening can partly reflect terminal decline rather than chronological age alone. Key Findings 2,411 older-adult records: Researchers analyzed longitudinal depressive-symptom data from the Interplay of Genes and Environments across …
TL;DR: A 2026 rat study in Hippocampus found that the dentate gyrus (DG), a hippocampal memory region, gained about 385,000 granule neurons from 2 to 18 months of age even though older development-born neurons were also being lost. Key Findings 385,000-cell net gain: Total DG granule neuron counts increased by about 385,000 cells from 2 …
TL;DR: A 2026 study in Epigenetics found that DNA methylation clocks, which estimate biological aging from chemical marks on DNA, gave substantially older age estimates in saliva than in two blood-derived samples from 91 early-to-mid-adult participants. Key Findings The sample included 91 adults: Researchers analyzed participants from a twin and sibling study with a mean …
TL;DR: A 2026 narrative review in the Japanese Journal of Radiology reported that Alzheimer’s brain positron emission tomography (PET) imaging has shifted from supportive diagnosis toward treatment selection because amyloid PET is now central to confirming eligibility for anti-amyloid antibody therapy. Key Findings Three PET roles: The review separated FDG-PET, amyloid PET, and tau PET …
TL;DR: A 2026 study in Aging Cell found that fasting and caloric restriction activated ADIOL, a steroid hormone, through an NHR-91-kynurenic acid pathway that improved several healthspan measures in worms without extending lifespan. Key Findings ADIOL was the central hormone: 5-androstene-3beta,17beta-diol (ADIOL) linked nutrient restriction to healthier function in C. elegans worms. NHR-91 was required: …
TL;DR: A 2026 medRxiv preprint found that older adults with Montreal Cognitive Assessment (MoCA)-defined mild cognitive impairment had less coordinated pulse-wave responses during a cognitive challenge than cognitively intact older adults. Key Findings Community cognitive-aging sample: The southern Taiwan dataset included 101 older adults: 12 reference participants, 50 people in a MoCA-defined mild cognitive impairment …
