TL;DR: A 2026 preprint in medRxiv linked higher neighborhood deprivation to faster DNA-methylation aging in 370 healthy adults, with lifetime adversity explaining part of the association and stronger direct effects among Black participants. Key Findings Yale sample anchored the test: The cross-sectional Yale Stress Center sample included 370 adults aged 18 to 50 years without …
TL;DR: A 2026 nationwide claims study in Integrative Medicine Research found that Korean traditional medicine care without recorded acupuncture claims had the lowest modeled costs and the highest 3-year QALYs among four menopausal-disorder treatment strategies, while acupuncture and integrative-care groups appeared to include sicker, higher-utilization patients. Key Findings 32,941 women: The retrospective cohort used Korean …
TL;DR: A 2026 open-label feasibility trial in IBRO Neuroscience Reports tested an AI-guided variable levodopa schedule in 5 people with Parkinson’s disease and found 4 patients improved on UPDRS, but the study was far too small and uncontrolled to prove efficacy. Key Findings Feasibility sample: The single-center trial enrolled 5 people with Parkinson’s disease after …
TL;DR: A 2026 randomized trial in Nature and Science of Sleep found that Sancai acupoint acupuncture reduced primary-insomnia severity more than sham acupuncture, with parallel improvements in sleep testing and peripheral 5-HT and BDNF biomarkers. Key Findings 76-person insomnia trial: Researchers randomized 38 patients to real Sancai acupuncture and 38 to sham acupuncture. 20 treatment …
TL;DR: A 2025 human proteomics study in Molecular Metabolism found that about 10 days of medically supervised water-only fasting caused weight loss and lower circulating amyloid beta proteins, but also increased inflammatory and platelet-activation markers. Key Findings 20 volunteers: The main cohort included 20 middle-aged adults with mean age 52.2 years and mean BMI 28.8 …
TL;DR: A 2026 systematic review and meta-analysis in Journal of Sleep Research found that agomelatine modestly improved subjective sleep quality versus placebo, but objective total sleep time did not significantly increase and somnolence reports were more frequent. Key Findings 25 RCTs: The review included 25 double-blind randomized controlled trials with 6,812 randomized participants. Subjective sleep …
TL;DR: A 2026 preprint posted on medRxiv found that iSupport-Malaysia, a culturally adapted multimedia dementia-caregiver platform, scored above the usual usability benchmark and was viewed as culturally appropriate by caregivers and healthcare professionals. Key Findings Four-phase adaptation: The WHO iSupport dementia program was translated into Bahasa Malaysia, culturally adapted, and rebuilt as multimedia e-learning. 23 …
TL;DR: A 2026 study in iScience found that migraine patients with patent foramen ovale had altered plasma metabolic profiles, with lower indoleacrylic acid and an IA-plus-hs-CRP marker pair showing exploratory discrimination in a validation cohort. Key Findings 30 discovery patients: Untargeted metabolomics compared 30 migraine patients with patent foramen ovale against 17 matched controls. 4,858 …
TL;DR: A 2026 systematic review in Preventive Medicine Reports found limited but suggestive randomized-trial evidence that smoking-cessation medications can help Indigenous adults quit, especially when paired with supportive or culturally tailored care. Key Findings 5 RCTs: The review found only 5 randomized controlled trials, totaling 1,633 participants, in American Indian, Alaska Native, and Maori adult …
TL;DR: A 2026 mouse study in Neuron found that exercise activates ventromedial hypothalamic SF1 neurons, and that this brain response is required for normal endurance gains after training. Key Findings VMH SF1 neurons: Exercise increased activity-linked Bdnf expression in steroidogenic factor-1 neurons in the ventromedial hypothalamus. Training plasticity: Repeated exercise increased both intrinsic excitability and …
