TL;DR: A 2026 review in Journal of Neuroinflammation proposed that Alzheimer microglial dysfunction can be understood as checkpoint collapse, where failed regulatory controls feed three interacting lipid, iron/ferroptosis, and inflammation/complement axes. Key Findings Review framework, not trial result: Alzheimer microglial evidence through April 2026 was synthesized rather than used to test a new drug or …
TL;DR: A 2026 systematic review in PLOS One found that ketogenic diet therapies were linked to more 50% seizure reductions in drug-resistant epilepsy, with clearer evidence in children and more uncertainty for near-complete seizure control, side effects, adherence, and quality of life. Key Findings 17 randomized trials were included: The review screened 1,193 records after …
TL;DR: A 2026 Molecular Psychiatry study found that common genetic influences on sustained attention were partly separable from genetic influences on executive function, using task-based cognition data from the AFFECT study and 23andMe participants. Key Findings More than 20,000 participants contributed task-based cognition data: Final GWAS sample sizes ranged from 10,129 people for lapse recovery …
TL;DR: A 2026 study in Journal of Neural Engineering reported that adding passive recordings from bidirectional deep brain stimulation (DBS) electrodes to scalp electroencephalography (EEG) improved simulated deep-brain source localization, especially near the implanted lead. Key Findings 72-channel scalp EEG: The simulations combined scalp EEG with 4-contact, 8-contact, or 40-contact DBS electrode configurations. Three noise …
TL;DR: Major depressive disorder and vitiligo may share immune-inflammatory gene signatures. In PLOS One in 2026, the analysis frames MAPK14 as a preliminary candidate marker that still needs clinical and laboratory validation. Key Findings Two public disease datasets were combined: The analysis used 128 major-depression blood samples and 64 controls from GEO, plus a small …
TL;DR: A 2026 review in Annals of Medicine argues that circadian rhythm disruption in major depressive disorder (MDD) reaches beyond poor sleep, linking clock-gene variation, sleep-wake timing, stress-hormone rhythms, melatonin signaling, and chronotherapy targets. Key Findings 264 million affected: The review frames MDD as a leading global disability cause affecting more than 264 million people. …
TL;DR: A 2026 systematic review and meta-analysis in Musculoskeletal Science and Practice found that people with carpal tunnel syndrome had higher blood markers tied to fibrosis and inflammation, along with lower vitamins and minerals, but the evidence was too heterogeneous for a diagnostic blood test. Key Findings 28-study review: Researchers analyzed 28 studies covering 2,840 …
TL;DR: A 2026 analysis in Brain, Behavior, & Immunity – Health of 827 middle-aged adults found that profiles combining intestinal-permeability biomarkers with age, cardiometabolic risk, or lifestyle factors were associated with smaller brain volumes and higher plasma neurofilament light in sex-specific patterns, with only the women’s profiles also associated with higher 4-year odds of neurological …
TL;DR: A 2026 systematic review and Bayesian meta-analysis in Journal of Medical Internet Research found that artificial intelligence models trained only on overnight pulse-oximetry oxygen-saturation data detected obstructive sleep apnea with 91.1% sensitivity and 88.4% specificity across 25 studies. Key Findings 25 studies and 23,171 participants were included: The review pooled adult studies that compared …
TL;DR: A 2026 Developmental Psychology randomized-trial follow-up found that children assigned to high-quality foster care after severe early deprivation had better adaptive functioning at age 18, especially in communication and socialization, than children who remained in care as usual. Key Findings Trial follow-up: The analysis used the Bucharest Early Intervention Project, a randomized trial comparing …
