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TL;DR: A 2026 systematic review and meta-analysis in Molecular Psychiatry found that CB-1 receptor blockade and cannabidiol reduced alcohol intake in animal models, but human alcohol-use-disorder evidence remained inconsistent and too thin to support a treatme…
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TL;DR: A 2026 meta-analysis in Journal of Medical Internet Research did not find a statistically significant reduction in Patient Health Questionnaire-9 (PHQ-9) depression scores with AI-driven chatbots, but emotionally responsive, structured, and frequent int…
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TL;DR: A 2026 study in International Clinical Psychopharmacology described a 40-year-old man whose dysphoria, anhedonia, amotivation, and fatigue appeared soon after olanzapine was changed to olanzapine-samidorphan and resolved after he returned to olanzapine…
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TL;DR: A 2026 medRxiv retrospective cohort study found that depression often followed bipolar manic or mixed episodes quickly, with 25% of manic episodes and 22% of mixed episodes transitioning to depression within 1 month. Key Findings First-month risk window…
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TL;DR: A 2026 study in Nature Communications reported that tubulin redirected Tau and alpha-synuclein condensates toward microtubule-building states, while tubulin loss pushed the same protein system toward toxic oligomers in cell models. Key Findings 36-hour…
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TL;DR: A 2026 mouse and cell study in Nature found that developing neurons can generate DNA double-strand breaks while moving through narrow brain tissue during migration, then usually repair those breaks without cell death. Key Findings Developing neurons: Th…
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TL;DR: A 2026 systematic review and meta-analysis in Pain Medicine found that Medicaid enrollment and preoperative benzodiazepine use had the largest pooled associations with new persistent opioid use after surgery among opioid-naive US adults. Key Findings 27…
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TL;DR: A 2026 secondary analysis in Drug and Alcohol Dependence found 4 cannabis craving trajectories during treatment, with the high-craving group showing more positive urine cannabinoid tests and higher baseline anxiety, depression, and obsessive-compulsive…
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TL;DR: A 2026 study in Neuropsychopharmacology found that 30 mg 2C-B produced acute subjective effects in healthy adults that were similar in overall intensity to 125 mg MDMA, shorter and less distressing than 25 mg psilocybin, and less cardiovascularly stimul…
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TL;DR: A 2026 study in Nature Communications found that proteotoxic stress can push neurons into karyoptosis, a cell-death pathway marked by nuclear lamina breakdown, nuclear-material expulsion, and dementia-linked tissue signatures. Key Findings Karyoptosis w…
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